OSMR - oncostatin M receptor Gene

Homo sapiens

Also known as OSMRB; PLCA1; IL-31RB; OSMRbeta; IL-31R-beta

Gene ID: 9180 | Gene type: protein coding

About OSMR

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:38,846,012-38,945,579 (from NCBI)

This gene has 5 transcripts (splice variants), 531 orthologues, 23 paralogues and is associated with 2 phenotypes. Ubiquitous expression in gall bladder (RPKM 13.2), placenta (RPKM 11.5) and 24 other tissues.

Summary

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

OSMR Products(6)

mRNA	Protein	Name
NM_001168355.3	NP_001161827.1	oncostatin-M-specific receptor subunit beta isoform 2 precursor
NM_001323504.2	NP_001310433.1	oncostatin-M-specific receptor subunit beta isoform 2 precursor
NM_001323505.2	NP_001310434.1	oncostatin-M-specific receptor subunit beta isoform 1 precursor
NM_001323506.2	NP_001310435.1	oncostatin-M-specific receptor subunit beta isoform 3 precursor
NM_001323507.2	NP_001310436.1	oncostatin-M-specific receptor subunit beta isoform 4 precursor
NM_003999.3	NP_003990.1	oncostatin-M-specific receptor subunit beta isoform 1 precursor

OSMR Protein Structure

fn3

0
200
400
600
800
979 a.a.

Protein Preferred Names

Protein Names

oncostatin-M-specific receptor subunit beta

IL-31 receptor subunit beta

Recombinant OSMR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72500	OSMR beta Protein, Human (712a.a, HEK293, His)	Q99650 (E28-S739)	≥95%
HY-P77456	OSMR beta Protein, Human (740a.a, HEK293, His)	Q99650 (M1-M740)	≥95%

Related Diseases

Diseases

Alias

Amyloidosis, Primary Localized Cutaneous, 1

PLCA1	Pca
Amyloidosis Ix	Familial Lichen Amyloidosis
Amyloidosis, Primary Cutaneous, 1	Pca1
Lichen Amyloidosis, Familial	Amyloidosis, Familial Cutaneous Lichen
Primary Localized Cutaneous Amyloidosis 1	Familial Primary Localized Cutaneous Amyloidosis-1
Amyloidosis Type 9	Plca
Primary Cutaneous Amyloidosis	Primary Localized Cutaneous Amyloidosis
Amyloidosis, Primary Cutaneous

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Lichen Amyloidosis

Amyloid Lichen	Lichen Amyloidosus
Amyloidosis, Primary Cutaneous

Macular Amyloidosis

Amyloidosis, Macular

Amyloidosis, Primary Localized Cutaneous, 3

Amyloidosis Cutis Dyschromica	PLCA3
Acd	Primary Localized Cutaneous Amyloidosis 3
Amyloidosis Cutis Dyschromia

Allergic Urticaria

Bone Cancer

Malignant Bone Neoplasm	Bone Carcinoma
Bone Neoplasms	Bone Neoplasm
Bone Tumour	Ca - Bone Cancer
Malignant Bone Tumour	Malignant Neoplasm Of Bone
Malignant Osseous Tumor	Neoplasm Of Bone
Osseous Tumor	Osteosarcoma Of Bone
Osteogenic Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09851	OSMR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	OSMR	VGNC	VGNC:44167
Mus musculus	OSMR	MGD	MGI:1330819
Bos taurus	OSMR	VGNC	VGNC:32475
Felis catus	OSMR	VGNC	VGNC:68659
Rattus norvegicus	OSMR	RGD	RGD:1302983
Macaca mulatta	OSMR	VGNC	VGNC:75721
Macaca fascicularis	OSMR	NCBI
Others	OSMR	NCBI