HSPA9 - heat shock protein family A (Hsp70) member 9 Gene

Also Known as CSA; MOT; MOT2; SAAN; CRP40; EVPLS; GRP75; PBP74; GRP-75; HSPA9B; SIDBA4; MTHSP75; HEL-S-124m

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3313

About HSPA9

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,553,756-138,575,401 (from NCBI)

This gene has 23 transcripts (splice variants), 234 orthologues, 13 paralogues and is associated with 4 phenotypes. Ubiquitous expression in adrenal (RPKM 109.2), thyroid (RPKM 92.6) and 25 other tissues.

Summary

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

HSPA9 Products (1)

mRNA	Protein	Name
NM_004134.7	NP_004125.3	stress-70 protein, mitochondrial precursor

HSPA9 Protein Structure

HSP70

0
200
400
600
679 a.a.

Protein Preferred Names	Protein Names
stress-70 protein, mitochondrial	75 kDa glucose-regulated protein

HSPA9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HSPA9	P38646	YKT6	Homo sapiens	A4D2J0	Y2H Array	25416956
Intra	HSPA9	P38646	YKT6	Homo sapiens	A4D2J0	Y2H Prey Pooling	25416956
Intra	HSPA9	P38646	GRPEL1	Homo sapiens	Q9HAV7	ATPase Assay	23263864
Intra	HSPA9	P38646	HSCB	Homo sapiens	Q8IWL3	BN-PAGE	24606901
Intra	HSPA9	P38646	GPBAR1	Homo sapiens	Q8TDU6	Anti Tag CoIP	31978385
Intra	HSPA9	P38646	GPBAR1	Homo sapiens	Q8TDU6	IF	31978385
Intra	HSPA9	P38646	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029
Intra	HSPA9	P38646	NELFB	Homo sapiens	Q8WX92	Display Tech	20195357
Intra	HSPA9	P38646	NELFB	Homo sapiens	Q8WX92	TAP	20195357
Intra	HSPA9	P38646	TP73	Homo sapiens	O15350	IF	22340593

Cross: Cross-species interaction Intra: Intraspecies interaction

HSPA9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83410	Grp75/MOT Antibody (YA3155)	WB	Human, Mouse, Rat
HY-P84290	Grp75/MOT Antibody (YA3987)	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Monkey, Rat
HY-P84290A	Grp75/MOT Antibody (YA3987)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Monkey, Rat

Related Diseases

Diseases	Alias
Even-Plus Syndrome	EVPLS Epiphyseal And Vertebral Dysplasia, Microtia, And Flat Nose, Plus Associated Malformations Epiphysial-Vertebral-Ear Dysplasia-Nose-Plus Associated Findings Syndrome
Anemia, Sideroblastic, 4	SIDBA4 Anemia, Sideroblastic, Type 4
Autosomal Recessive Sideroblastic Anemia	Arsa Congenital Sideroblastic Anemia Hereditary Sideroblastic Anemia
Sideroblastic Anemia	Anemia Sideroblastic Anemia, Sideroblastic Anemia, Hypochromic With Iron Loading
Friedreich Ataxia	Friedreich Ataxia 1 FRDA Friedreich Ataxia With Retained Reflexes Frda1 Fa Friedreich'S Ataxia Hereditary Spinal Ataxia Fa1 Friedreich'S Tabes Hereditary Spinal Sclerosis Spinocerebellar Ataxia, Friedreich Friedreich Spinocerebellar Ataxia Friedrich'S Ataxia
Codas Syndrome	Cerebral, Ocular, Dental, Auricular, And Skeletal Anomalies Syndrome Cerebral, Ocular, Dental, Auricular, And Skeletal Syndrome Cerebro-Oculo-Dento-Auriculo-Skeletal Syndrome Cerebrooculodentoauriculoskeletal Syndrome CODASS Cerebral, Ocular, Dental, Auricular, Skeletal Syndrome
Leukodystrophy, Hypomyelinating, 4	Mitochondrial Hsp60 Chaperonopathy Hypomyelinating Leukodystrophy 4 HLD4 Mitchap60 Disease Pelizaeus-Merzbacher-Like Disease Due To Hspd1 Mutation Mitchap-60 Disease Leukodystrophy, Hypomyelinating, Type 4
Complement Component 7 Deficiency	C7 Deficiency C7D
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Perrault Syndrome	Gonadal Dysgenesis, Xx Type, With Deafness Ovarian Dysgenesis With Sensorineural Deafness Gonadal Dysgenesis, Xx Type Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance Xx Gonodal Dysgenesis-Deafness Syndrome Xx Gonodal Dysgenesis-Hearing Loss Syndrome Gonadal Dysgenesis Xx Type Deafness
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152153	GRP78-IN-3	Inhibitor	99.88%	Unkown
HY-RS06437	HSPA9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18519	Hspa9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25001	Hspa9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HSPA9	VGNC	VGNC:52243
Mus musculus	HSPA9	MGD	MGI:96245
Macaca mulatta	HSPA9	VGNC	VGNC:84389
Felis catus	HSPA9	VGNC	VGNC:102228
Rattus norvegicus	HSPA9	RGD	RGD:1311806
Canis familiaris	HSPA9	VGNC	VGNC:51725
Others	HSPA9	NCBI