GRPEL1 - GrpE like 1, mitochondrial Gene

Also Known as GrpE; HMGE; mt-GrpE#1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80273

About GRPEL1

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:7,058,895-7,068,064 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 26.2), kidney (RPKM 13.9) and 25 other tissues.

Summary

Enables identical protein binding activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial matrix and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GRPEL1 Products (1)

mRNA Protein Name
NM_025196.4 NP_079472.1 grpE protein homolog 1, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables unfolded protein binding IDA
IDA: Inferred from direct assay
11311562 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
11311562 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRPEL1 Protein Structure

GrpE

GrpE: GrpE (47 - 215)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

grpE protein homolog 1, mitochondrial

  • GrpE-like protein cochaperone

GRPEL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GRPEL1 Q9HAV7 GRPEL1 Homo sapiens Q9HAV7
Complementation
32296183
Intra
GRPEL1 Q9HAV7 HSPA9 Homo sapiens P38646
Crosslink
30021884
Intra
GRPEL1 Q9HAV7 HSPA9 Homo sapiens P38646
Anti Tag CoIP
33961781
Intra
GRPEL1 Q9HAV7 GRPEL1 Homo sapiens Q9HAV7
MAPPIT
32296183
Intra
GRPEL1 Q9HAV7 GRPEL1 Homo sapiens Q9HAV7
Y2H Prey Pooling
32296183
Intra
GRPEL1 Q9HAV7 HSPA9 Homo sapiens P38646
Anti Tag CoIP
28514442
Intra
GRPEL1 Q9HAV7 GRPEL1 Homo sapiens Q9HAV7
Validated Y2H
32296183
Intra
GRPEL1 Q9HAV7 GRPEL1 Homo sapiens Q9HAV7
Y2H Array
32296183
Intra
GRPEL1 Q9HAV7 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
GRPEL1 Q9HAV7 GALT Homo sapiens P07902
Y2H Prey Pooling
32296183
Intra
GRPEL1 Q9HAV7 GALT Homo sapiens P07902
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Human Monocytic Ehrlichiosis

  • Ehrlichiosis Chafeensis

  • Hme

  • Human Ehrlichial Infection, Human Monocytic Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05845 GRPEL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GRPEL1 MGD MGI:1334417
Macaca mulatta GRPEL1 VGNC VGNC:106588
Rattus norvegicus GRPEL1 RGD RGD:70947
Felis catus GRPEL1 VGNC VGNC:107337
Bos taurus GRPEL1 VGNC VGNC:29665
Canis familiaris GRPEL1 VGNC VGNC:41517
Others GRPEL1 NCBI