ATP5IF1 - ATP synthase inhibitory factor subunit 1 Gene

Also Known as IP; ATPI; ATPIP; ATPIF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93974

About ATP5IF1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,236,124-28,238,100 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 112 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 44.4), colon (RPKM 33.7) and 25 other tissues.

Summary

This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

ATP5IF1 Products (3)

mRNA Protein Name
NM_016311.5 NP_057395.1 ATPase inhibitor, mitochondrial isoform 1 precursor
NM_178190.3 NP_835497.1 ATPase inhibitor, mitochondrial isoform 2 precursor
NM_178191.3 NP_835498.1 ATPase inhibitor, mitochondrial isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IDA
IDA: Inferred from direct assay
15528193 GOA
enables ATPase inhibitor activity IDA
IDA: Inferred from direct assay
12110673 GOA
enables ATPase inhibitor activity IMP
IMP: Inferred from mutant phenotype
24005319 GOA
enables angiostatin binding IDA
IDA: Inferred from direct assay
15528193 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
21106936 GOA
enables mitochondrial proton-transporting ATP synthase complex binding IDA
IDA: Inferred from direct assay
12110673 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
24005319 GOA
involved in negative regulation of ATP-dependent activity IMP
IMP: Inferred from mutant phenotype
24005319 GOA
involved in negative regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
15528193 GOA
involved in negative regulation of hydrolase activity IDA
IDA: Inferred from direct assay
15528193 GOA
involved in positive regulation of proteolysis involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
24005319 GOA
involved in positive regulation of type 2 mitophagy IMP
IMP: Inferred from mutant phenotype
24005319 GOA
involved in regulation of ATP metabolic process IMP
IMP: Inferred from mutant phenotype
24005319 GOA
involved in regulation of protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
24005319 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15528193 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
12110673 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5IF1 Protein Structure

IATP

IATP: Mitochondrial ATPase inhibitor, IATP (6 - 93)

  • 0
  • 100
  • 106 a.a.
Protein Preferred Names Protein Names

ATPase inhibitor, mitochondrial

  • ATP synthase F1 subunit epsilon

ATP5IF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATP5IF1 Q9UII2 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 MECP2 Homo sapiens P51608
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 MECP2 Homo sapiens P51608
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 CHAT Homo sapiens P28329-3
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 TOR1A Homo sapiens O14656-2
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 TOR1A Homo sapiens O14656-2
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 TOR1A Homo sapiens O14656-2
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 GRN Homo sapiens P28799-2
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 GRN Homo sapiens P28799-2
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 GRN Homo sapiens P28799-2
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 OSMR Homo sapiens Q99650
Confocal
32807793
Intra
ATP5IF1 Q9UII2 NUP58 Homo sapiens Q9BVL2
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 NUP58 Homo sapiens Q9BVL2
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 ATP5F1B Homo sapiens P06576
Anti Tag CoIP
33961781
Intra
ATP5IF1 Q9UII2 ATP5F1B Homo sapiens P06576
Crosslink
30021884
Intra
ATP5IF1 Q9UII2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
ATP5IF1 Q9UII2 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 A2M Homo sapiens P01023
Y2H Array
32814053
Intra
ATP5IF1 Q9UII2 A2M Homo sapiens P01023
Y2H Pooling
32814053
Intra
ATP5IF1 Q9UII2 A2M Homo sapiens P01023
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

ATP5IF1 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P84865 ATPIF1 Antibody (YA4562) IHC-P, ICC/IF, FC, ELISA Human
HY-P84865A ATPIF1 Antibody (YA4562)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Fallopian Tube Adenocarcinoma

  • Adenocarcinoma Of The Fallopian Tube
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS01202 ATP5F1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01203 ATP5F1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01204 ATP5F1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19833 Atp5f1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01205 ATP5F1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01206 ATP5F1E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01207 ATP5IF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01208 ATP5MC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18205 Atp5f1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20209 Atp5if1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21229 Atp5f1c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21988 Atp5f1d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24682 Atp5f1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26330 Atp5f1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26714 Atp5if1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27746 Atp5f1c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28506 Atp5f1d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ATP5IF1 MGD MGI:1196457
Canis familiaris ATP5IF1 VGNC VGNC:38292
Felis catus ATP5IF1 VGNC VGNC:68724
Macaca mulatta ATP5IF1 VGNC VGNC:70192
Rattus norvegicus ATP5IF1 RGD RGD:2181
Others ATP5IF1 NCBI