Liposomal Curcumin
Based on 1 Customer Validation
Liposomal Curcumin is an orally active liposomal curcumin nanoformulation with antitumor, anti-neuroinflammatory, and other activities. Liposomal Curcumin mediates caspase-dependent apoptosis as well as epigenetic regulation represented by DNA hypomethylation and miR-223 upregulation through the modulation of multiple core signaling axes, including Akt/ERK‑NF‑κB, Autophagy, and endoplasmic reticulum stress. Liposomal Curcumin can be used for research on diseases such as neuroinflammation, type I diabetes, and non-small cell lung cancer.
For research use only. We do not sell to patients.
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
All Caspase Isoforms
More
Biological Activity
Description
|
IL-6 |
IL-8 |
TNF-α |
MMP-9 |
MMP-2 |
In Vitro
Liposomal Curcumin (0.01 µM; 30 min pre-incubation) protects mouse organotypic cortical slices from LPS-induced cytotoxicity, reduces IL1β, IL6, and TNFα expression, and attenuates markers of reactive astrogliosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:human microglia HMC3 and human astrocytes SVGA
-
Concentration:0.0001, 0.001, 0.01, 0.1, 0.2, 0.5, 1, 2, 5, 10, 20 µM
-
Incubation Time:72 h
-
Result:Did not impair viability of HMC3 and SVGA cells.
-
Cell Line:human microglia HMC3, human astrocytes SVGA
-
Concentration:0.01 µM
100 ng/mL LPS -
Incubation Time:30 min (LipoCur pre-incubation); 24 h (LPS)
-
Result:Pre‑incubation mitigated LPS‑evoked IL6, IL1β, TGFβ and TNFα up‑regulation, though high variation caused occasional loss of statistical significance, and produced no gene expression changes under non‑inflammatory conditions.
Pre‑incubation markedly suppressed cytokine‑triggered tenascin‑C, fibronectin and nestin induction to near‑control levels, and produced no gene alterations under cytokine‑free conditions.
-
Cell Line:A549 human lung adenocarcinoma cells
-
Concentration:2.5, 5, 10, 20 μM
-
Incubation Time:24 h
-
Result:Suppressed A549 cell proliferation starting at 2.5 μM in a dose‑dependent manner, and identified 5 μM as the highest non‑toxic concentration for normal BCi‑NS1.1 bronchial epithelial cells.
-
Cell Line:A549 cells
-
Concentration:2.5, 5 μM
-
Incubation Time:24 h
-
Result:Reduced A549 colony counts by 68.58% at 2.5 μM and 92.07% at 5 μM relative to untreated controls.
-
Cell Line:A549 cells
-
Concentration:2.5, 5 μM
-
Incubation Time:24 h
-
Result:Prevented A549 wound closure, yielding 26.68% closure reduction at 2.5 μM and 41.36% at 5.0 μM relative to untreated controls, with significant inhibitory effects observed at 5.0 μM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Wistar-Bratislava albino (male, 200-250 g)[3]
-
Dosage:10, 20 mg/kg b.w.
-
Administration:i.p.; single dose on day 1, 30 min before first gentamicin dose
-
Result:Exhibited dose-dependent regulation on oxidative stress markers, matrix metalloproteinases and renal function indices: higher 20 mg/kg dose lowered MDA, NOx, TOS, MMP‑2, MMP‑9, creatinine, urea and BUN, while elevating catalase and TAC relative to the 10 mg/kg group.
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Research Protocol for Epigenomic Data Analysis
- Annexin V plus membrane-impermeant dye apoptosis staining
- Autophagy
- Apoptosis Solutions
- Lysosome and acidic-vesicle live-cell staining
- Research Protocol for Neurological Diseases
- Macroautophagy Solutions
- Research Protocol for Metabolic Diseases
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
-
Appearance Solid
-
Color Yellow to orange
-
SMILES
[Liposomal Curcumin]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
-
Data Sheet (283 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Liposomal Curcumin Related Classifications
HY-177840 Related Classifications
Powered by Bioz
Keywords
- Liposomal Curcumin
- Liposome
- Drug Derivative
- Caspase
- Interleukin Related
- TNF Receptor
- Transmembrane Glycoprotein
- MMP
- Autophagy
- Apoptosis
- Drug derivative
- IL
- Tumor Necrosis Factor Receptor
- TNFR
- Matrix metalloproteinases
- apoptosis
- autophagy
- gentamicin-induced nephrotoxicity
- neuroinflammation
- non-small cell lung cancer
- oxidative stress
- reactive astrogliosis
- type I diabetes mellitus
- Inhibitor
- inhibitor
- inhibit