IL23R - interleukin 23 receptor Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 149233

About IL23R

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:67,138,637-67,265,903 (from NCBI)

This gene has 33 transcripts (splice variants), 529 orthologues, 23 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]

IL23R Products (1)

mRNA	Protein	Name
NM_144701.3	NP_653302.2	interleukin-23 receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine receptor activity	IDA IDA: Inferred from direct assay	29287995	GOA
contributes to interleukin-12 receptor binding	IPI IPI: Inferred from physical interaction	12023369	GOA
contributes to interleukin-23 binding	IPI IPI: Inferred from physical interaction	12023369	GOA
contributes to interleukin-23 receptor activity	IDA IDA: Inferred from direct assay	12023369	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12023369	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in interleukin-23-mediated signaling pathway	IDA IDA: Inferred from direct assay	29287995	GOA
involved in negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	16751425	GOA
involved in positive regulation of T-helper 1 type immune response	IDA IDA: Inferred from direct assay	15114670	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	12421946	GOA
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	20027291	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	11114383	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12023369	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	12023369	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cell surface	IDA IDA: Inferred from direct assay	12023369	GOA
part of interleukin-23 receptor complex	IDA IDA: Inferred from direct assay	12023369	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-23 receptor	IL-23 receptor

IL23R Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL23R	Q5VWK5	IL23A	Homo sapiens	Q9NPF7	ELISA	12023369
Intra	IL23R	Q5VWK5	C1D	Homo sapiens	Q13901	Y2H Array	25416956
Intra	IL23R	Q5VWK5	C1D	Homo sapiens	Q13901	Y2H Prey Pooling	25416956
Intra	IL23R	Q5VWK5	C1D	Homo sapiens	Q13901	Validated Y2H	25416956
Cross	IL23R	Q5VWK5	Jak2	Mus musculus	Q62120	Anti Bait CoIP	12023369

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL23R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70680	IL-23R Protein, Human (330a.a, HEK293, Fc)	Q5VWK5-1 (G24-D353)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73196	IL-23R Protein, Human (HEK293, Fc)	AAM44229.1 (G24-D353)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73886	IL-23R Protein, Human (HEK293, His)	AAM44229.1 (G24-D353)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78470	IL-23R Protein, Human (HEK293, mFc)	Q5VWK5-1 (G24-G355)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78856	IL-23R Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q5VWK5-1 (G24-G355)	≥ 95%, as determined by reducing SDS-PAGE.

IL23R Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83656	IL-23R Antibody	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 17	Inflammatory Bowel Disease 17, Protection Against IBD17 Bowel Disease, Inflammatory, Type 17
Psoriasis 7	PSORS7 Psoriasis 7, Susceptibility To Psoriasis Susceptibility 7 Psoriasis Psoriasis Vulgaris Pv
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Colitis
Spondylitis
Psoriasis
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Inflammatory Bowel Disease 6	IBD6
Inflammatory Bowel Disease 5	IBD5
Achalasia	Cardiospasm Achalasia Of Cardia Esophageal Achalasia Hypertensive Lower Esophageal Sphincter Idiopathic Achalasia Achalasia Cardia Idiopathic Achalasia Of Esophagus Primary Achalasia Achalasia Of Esophagus Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter Aperistalsis Of The Oesophagus Achalasia Of Oesophagus Oesophageal Achalasia Achalasia Nos Cardia Spasm Cardia Achalasia Oesophageal Cardiospasm Oesophagus Achalasia Reflex Cardiospasm
Uveitis
Takayasu Arteritis	Aortic Arch Syndrome Pulseless Disease Takayasu'S Arteritis Idiopathic Aortitis Young Female Arteritis Aortic Arch Arteritis Aortic Arches Defect Aortic Arch Defects Takayasu Disease Aortic Arch Syndromes Takayasu'S Disease Ta Obliterative Aortitis Aortic Arch Giant-Cell Arteritis Subclavian-Carotid Obstruction Syndrome Idiopathic Medial Aortopathy And Arteriopathy Takayasu Syndrome Obliterative Brachiocephalic Arteritis Syndrome Raeder-Harbitz Syndrome Chronic Subclavian-Carotid Obstruction Syndrome Giant-Cell Aortitis Takayasu Aortitis Nonspecific Aortoarteritis Sclerosing Aortitis And Arteritis Martorell 2 Syndrome Young Female Aortic Arch Arteritis Syndrome
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Spondyloarthropathy	Spondylarthropathies Spondarthropathy Spondylarthrosis Spondyloarthropathy, Susceptibility To Spondylarthritis
Lyme Disease	Lyme Borreliosis Lyme Neuroborreliosis Borreliosis Borrelia Burgdorferi Infection Neuroborreliosis Bannwarth Syndrome Bannworth'S Syndrome Neurological Lyme Disease B. Burgdorferi Infection Borreliosis, Lyme Infection By Borrelia Burgdorferi Infection Due To Borrelia Burgdorferi Sensu Lato Lym Borrelia Infections
Autoimmune Disease Of Skin And Connective Tissue
Anterior Uveitis	Iridocyclitis Uveitis, Anterior Acute Anterior Uveitis Uveokeratitis Keratouveitis Cyclitis Intraocular Inflammation Kerato-Uveitis Keratoiritis Iritis Uveitis Nos Uveal Inflammation Anterior Chamber Cell
Inflammatory Bowel Disease 3	IBD3
Spondyloarthropathy 1	Ankylosing Spondylitis Spondyloarthropathy, Susceptibility To, 1 SPDA1 Marie-Strumpell Spondylitis Bechterew Syndrome Spa Spondylarthritis Ankylopoietica Reiter Syndrome Ankylosing Spondylitis, Susceptibility To Bekhterev Syndrome Bekhterev'S Disease Marie-Strumpell Disease Axial Spondylarthritis Bechterew Disease Marie-Struempell Disease Spondylitis Ankylopoietica Spondyloarthritis Spondyloarthritis Ankylopoietica Spas Ankylosing Spondylarthritis Psoriatic Arthritis Reactive Arthritis Rheumatoid Spondylitis Spondylitis Ankylosans Spondylitis Ankylosing Spondylitis, Ankylosing Spondylarthropathies Arthritis, Psoriatic Arthritis, Reactive
Psoriasis 1	Psoriasis Vulgaris PSORS1 Psoriasis 1, Susceptibility To Psoriasis Susceptibility 1 Psoriasis Pv Psoriasis, Susceptibility To, Type 1
Vogt-Koyanagi-Harada Disease	Uveomeningoencephalitic Syndrome Uveomenigitic Syndrome Vogt-Koyanagi-Harada Syndrome Harada'S Disease Vogt-Koyanagi Syndrome Vkh Disease Vkh Syndrome Vkh
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Panuveitis	Diffuse Uveitis Total Uveitis Inflammation Of The Whole Uveal Tract
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Autoimmune Disease Of Cardiovascular System
Hypopyon
Autoimmune Disease Of Gastrointestinal Tract
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly
Aphthous Stomatitis	Oral Ulcer Canker Sore Aphtha Aphthous Ulceration Oral Aphthae Oral Aphthous Ulcer Canker Sores Stomatitis, Aphthous Minor Oral Aphthous Ulceration
Uveal Disease	Uveal Diseases
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Autoimmune Disease Of Musculoskeletal System
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99737	Mirikizumab	Inhibitor	99.88%	Unkown

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10723	IL-23R inhibitor peptide-1	Inhibitor	99.85%	Unkown
HY-133552	RORγt Inverse agonist 10	Antagonist	99.13%	Unkown
HY-N0620	Mulberroside C		99.77%	Unkown
HY-RS06742	IL23R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174616	Human IL23R mRNA		/	Unkown
HY-RS16795	Il23r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23236	Il23r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992242	Anti-IL-23R Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IL23R	VGNC	VGNC:41973
Felis catus	IL23R	VGNC	VGNC:62908
Macaca mulatta	IL23R	VGNC	VGNC:73626
Mus musculus	IL23R	MGD	MGI:2181693
Bos taurus	IL23R	VGNC	VGNC:30147
Rattus norvegicus	IL23R	RGD	RGD:1586368
Others	IL23R	NCBI