IL-23R Protein, Human (HEK293, His)
Based on 1 Customer Validation
The IL-23R protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. IL-23R Protein, Human (HEK293, His) is the recombinant human-derived IL-23R protein, expressed by HEK293 , with C-10*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The IL-23R protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. IL-23R Protein, Human (HEK293, His) is the recombinant human-derived IL-23R protein, expressed by HEK293 , with C-10*His labeled tag.
Background
The IL-23R protein plays a critical role in immune response as it forms the interleukin-23 receptor by associating with IL12RB1. It binds to IL23 and triggers the activation of T-cells, NK cells, and potentially certain macrophage/myeloid cells through the Jak-Stat signaling cascade. IL23 is involved in both innate and adaptive immunity, and it likely contributes to the acute response to infection in peripheral tissues. Moreover, IL23 is implicated in autoimmune inflammatory diseases and has been shown to be important in tumorigenesis. When IL12RB1 is present, IL-23R forms a heterodimer, which acts as the IL-23 receptor. It interacts with JAK2 and, in the presence of IL23, activates STAT3.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-10*His
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Accession
AAM44229.1 (G24-D353)
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Molecular Construction
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N-term
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IL-23R (G24-D353)
Accession # AAM44229.1 -
His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
IL23R; IL-23 Receptor; Interleukin 23 Receptor; IL23RL1-THE1A; Interleukin-23 Receptor; PSORS7; IL-23R
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AA Sequence
GITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSPFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGD
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Predicted Molecular Mass
39.3 kDa
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Molecular Weight
Approximately 50-55 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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