IL-23R Protein, Rhesus Macaque (HEK293, Fc)

Interleukin 23 receptor is a subunit of the receptor for IL23A/IL23. Interleukin 23 receptor associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. IL-23R Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.

Interleukin 23 receptor is a subunit of the receptor for IL23A/IL23. Interleukin 23 receptor pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Interleukin 23 receptor associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Interleukin 23 receptor contributes to interleukin-12 receptor binding and contributes to interleukin-23 receptor activity. Interleukin 23 receptor is involved_in defense response to Gram-negative bacterium and positive regulation of T cell proliferation^{[1][2][3][4][5]}.

Rhesus Macaque

HEK293

C-hFc

F6XR82 (G24-D353)

700440  [NCBI]

Partial

GITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRQLHFYKNGIKERFEITRINKTTARLWYKNFLEPHASMYCTAECPNHFQETLICGKDISSGYPPDVPDEVTCVIYEYSGNMTCTWNAGKLTYVDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAENALGMEESKQLQIHLDDIVIPSASIISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATADQTWNVKEFDTNFTYVQQSEFYLEPNIKYIFQVRCQETGKRYWQAWSSPFFHKTPETVPQVTSKSSQHNTWNSGLTVASISTGHLTSDNRED

≥ 90%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.