Penciclovir sodium
Based on 1 publication(s) in Google Scholar
Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse.
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- CAS. Nr.: 97845-62-0
- Formel: C10H14N5NaO3
- Molecular Weight:275.24
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Biologische Aktivität
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HSV-1 0.5 μg/mL (EC50) |
HSV-2 0.8 μg/mL (EC50) |
Penciclovir sodium (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1].
Penciclovir sodium (0-100 µg/ml) shows no-toxic to uninfected human cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells
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Concentration:0-100 µg/ml
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Incubation Time:
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Result:Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Three-week-old female Balb/c mice[2]
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Dosage:100 mg/kg
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Administration:S.c.; daily for 5 days
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Result:Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 97845-62-0
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Molecular Weight 275.24
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Formel C10H14N5NaO3
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SMILES
OCC(CO[Na])CCN1C2=C(C(NC(N)=N2)=O)N=C1
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Synonyms
VSA 671 sodium; BRL 39123A; BRL 39123D
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
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