2. Anti-infection
  3. HSV
  4. Penciclovir sodium

Penciclovir sodium  (Synonyms: VSA 671 sodium; BRL 39123A; BRL 39123D)

Cat. No.: HY-107739
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Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse.

For research use only. We do not sell to patients.

Penciclovir sodium Chemical Structure

Penciclovir sodium Chemical Structure

CAS No. : 97845-62-0

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Penciclovir sodium Related Antibodies

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Description

Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse[1][2].

IC50 & Target[1]

HSV-1

0.5 μg/mL (EC50)

HSV-2

0.8 μg/mL (EC50)

In Vitro

Penciclovir sodium (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1].
Penciclovir sodium (0-100 µg/ml) shows no-toxic to uninfected human cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Penciclovir sodium Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells
Concentration: 0-100 µg/ml
Incubation Time:
Result: Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.
In Vivo

Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Three-week-old female Balb/c mice[2]
Dosage: 100 mg/kg
Administration: S.c.; daily for 5 days
Result: Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.
Clinical Trial
Molecular Weight

275.24

Formula

C10H14N5NaO3
CAS No.
SMILES

OCC(CO[Na])CCN1C2=C(C(NC(N)=N2)=O)N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Penciclovir sodium Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penciclovir97845-62-0VSA 671 BRL 39123A BRL 39123DVSA671VSA-671HSVHerpes simplex virusanti-herpesvirusno-toxicmortalityInhibitorinhibitorinhibit

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