97845-62-0
97845-62-0
Chemical Structure
Penciclovir sodium
Synonym(s): VSA 671 sodium; BRL 39123A; BRL 39123D
- CAS 番号: 97845-62-0
- Formula:C10H14N5NaO3
- Molecular Weight:275.24
IUPAC Name: sodium 4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)butan-1-olate
InChIKey: BRPTUOYNOCSFRJ-UHFFFAOYSA-N
SMILES: OCC(CO[Na])CCN1C2=C(C(NC(N)=N2)=O)N=C1
Biological Activity: Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse[1][2].
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Penciclovir sodium | Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse. | |||||||||||||||||||||
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References
- [1]. M.R. Boyd, et al. Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern. Antiviral Chemistry and Chemotherapy, 1993, (1): 3-11.
- [2]. de la Fuente R, et al. The acyclic nucleoside analogue penciclovir is a potent inhibitor of equine herpesvirus type 1 (EHV-1) in tissue culture and in a murine model. Antiviral Res. 1992 May;18(1):77-89. [Content Brief]
