1. Epigenetics
    Neuronal Signaling
    Anti-infection
  2. Histone Demethylase
    Monoamine Oxidase
    HSV
  3. OG-L002

OG-L002 

Cat. No.: HY-19333
Handling Instructions

OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes.

For research use only. We do not sell to patients.

OG-L002 Chemical Structure

OG-L002 Chemical Structure

CAS No. : 1357302-64-7

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Description

OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes[1].

IC50 & Target

IC50: 0.02 μM (LSD1), 1.38 μM (MAO-A), 0.72 μM (MAO-B), HSV IE[1]

In Vitro

OG-L002 inhibits viral IE gene expression in both cells with a significantly reduced IC50 (IC50: ~10 µM in HeLa cells; IC50: ~3 µM in HFF cells) relative to the control MAOI TCP (IC50: ~1 mM)[1].

In Vivo

OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection[1].

Animal Model: 4-week-old BALB/c female mice[1]
Dosage: 6, 20, 40 mg/kg
Administration: Intraperitoneal; daily; for 7 days
Result: Reduced the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection.
Molecular Weight

225.29

Formula

C₁₅H₁₅NO

CAS No.

1357302-64-7

SMILES

OC1=CC(C2=CC=C([[email protected]@H]3[[email protected]@H](N)C3)C=C2)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

OG-L002Histone DemethylaseMonoamine OxidaseHSVMAOHerpes simplex virusLSD1monoamineoxidasesMAO-AMAO-BIEInhibitorinhibitorinhibit

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OG-L002
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