1. Epigenetics
    Neuronal Signaling
    Anti-infection
  2. Histone Demethylase
    Monoamine Oxidase
    HSV
  3. OG-L002

OG-L002 

Cat. No.: HY-19333 Purity: 99.71% ee.: 99.52%
Handling Instructions

OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes.

For research use only. We do not sell to patients.

OG-L002 Chemical Structure

OG-L002 Chemical Structure

CAS No. : 1357302-64-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 62 In-stock
Estimated Time of Arrival: December 31
5 mg USD 125 In-stock
Estimated Time of Arrival: December 31
10 mg USD 215 In-stock
Estimated Time of Arrival: December 31
50 mg USD 645 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes[1].

IC50 & Target

IC50: 0.02 μM (LSD1), 1.38 μM (MAO-A), 0.72 μM (MAO-B), HSV IE[1]

In Vitro

OG-L002 inhibits viral IE gene expression in both cells with a significantly reduced IC50 (IC50: ~10 µM in HeLa cells; IC50: ~3 µM in HFF cells) relative to the control MAOI TCP (IC50: ~1 mM)[1].

In Vivo

OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection[1].

Animal Model: 4-week-old BALB/c female mice[1]
Dosage: 6, 20, 40 mg/kg
Administration: Intraperitoneal; daily; for 7 days
Result: Reduced the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection.
Molecular Weight

225.29

Formula

C₁₅H₁₅NO

CAS No.

1357302-64-7

SMILES

OC1=CC(C2=CC=C([[email protected]@H]3[[email protected]@H](N)C3)C=C2)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1109.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4387 mL 22.1936 mL 44.3872 mL
5 mM 0.8877 mL 4.4387 mL 8.8774 mL
10 mM 0.4439 mL 2.2194 mL 4.4387 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (7.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (7.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (7.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.71% ee.: 99.52%

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Keywords:

OG-L002Histone DemethylaseMonoamine OxidaseHSVMAOHerpes simplex virusLSD1monoamineoxidasesMAO-AMAO-BIEInhibitorinhibitorinhibit

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OG-L002
Cat. No.:
HY-19333
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