2. Epigenetics
    Neuronal Signaling
    Anti-infection
  3. Histone Demethylase
    Monoamine Oxidase
    HSV
  4. OG-L002

OG-L002 

Cat. No.: HY-19333 Purity: 99.55%
COA Handling Instructions

OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes.

For research use only. We do not sell to patients.

OG-L002 Chemical Structure

OG-L002 Chemical Structure

CAS No. : 1357302-64-7

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Solution
10 mM * 1 mL in DMSO USD 62 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
5 mg USD 125 In-stock
Estimated Time of Arrival: December 31
10 mg USD 215 In-stock
Estimated Time of Arrival: December 31
50 mg USD 645 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE OG-L002

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MAO-A MAO-B

  • Biological Activity

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  • Customer Review

Description

OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes[1].

IC50 & Target

IC50: 0.02 μM (LSD1), 1.38 μM (MAO-A), 0.72 μM (MAO-B), HSV IE[1]
In Vitro

OG-L002 inhibits viral IE gene expression in both cells with a significantly reduced IC50 (IC50: ~10 µM in HeLa cells; IC50: ~3 µM in HFF cells) relative to the control MAOI TCP (IC50: ~1 mM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-week-old BALB/c female mice[1]
Dosage: 6, 20, 40 mg/kg
Administration: Intraperitoneal; daily; for 7 days
Result: Reduced the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection.
Molecular Weight

225.29

Appearance

Solid

Formula

C15H15NO
CAS No.
SMILES

OC1=CC(C2=CC=C([[email protected]@H]3[[email protected]@H](N)C3)C=C2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1109.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4387 mL 22.1936 mL 44.3872 mL
5 mM 0.8877 mL 4.4387 mL 8.8774 mL
10 mM 0.4439 mL 2.2194 mL 4.4387 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (7.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (7.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (7.41 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.55%

COA (244 KB) LCMS (272 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

OG-L0021357302-64-7Histone DemethylaseMonoamine OxidaseHSVMAOHerpes simplex virusLSD1monoamineoxidasesMAO-AMAO-BIEInhibitorinhibitorinhibit

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