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Cat. No.: HY-19333A

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OG-L002 hydrochloride

Name: OG-L002 hydrochloride
Brand: MedChemExpress
SKU: HY-19333A
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2 Cited Publications

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Based on 2 publication(s) in Google Scholar

OG-L002 hydrochloride is a potent and highly selective LSD1 inhibitor with an IC₅₀ of 0.02 μM. OG-L002 hydrochloride is a potent monoamine oxidases (MAO) inhibitor with IC₅₀s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 hydrochloride potently inhibits the expression of HSV IE genes.

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CAS No.: 1357299-45-6
Formule: C₁₅H₁₆ClNO
Masse moléculaire:261.75

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

OG-L002 hydrochloride Chemical Structure

CAS No.: 1357299-45-6

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OG-L002

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Pureté et documentation
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Activité biologique

Description

IC₅₀ & Target

IC50 & Target: IC50: 0.02 μM (LSD1), 1.38 μM (MAO-A), 0.72 μM (MAO-B), HSV IE^[1]

Voir tous les produits spécifiques à Isoform Histone Demethylase :

Voir tous les produits spécifiques à Isoform Monoamine Oxidase :

MAO-A
MAO-B

Voir tous les produits spécifiques à Isoform HSV :

In Vitro

OG-L002 inhibits viral IE gene expression in both cells with a significantly reduced IC₅₀ (IC₅₀: ~10 μM in HeLa cells; IC₅₀: ~3 μM in HFF cells) relative to the control MAOI TCP (IC₅₀: ~1 mM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection^[1]. OG-L002 is a potent and highly selective LSD1 inhibitor with an IC₅₀ of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC₅₀s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

RNA extraction experimental

Chemical Information

CAS No. 1357299-45-6
Masse moléculaire 261.75
Formule C₁₅H₁₆ClNO
SMILES

OC1=CC(C2=CC=C([C@@H]3[C@@H](N)C3)C=C2)=CC=C1.[H]Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Clin Exp Med

Corin: a dual inhibitor for KDM1A/HDAC1, suppresses hepatocellular carcinoma by triggering cuproptosis. [Abstract]

2025 Nov 25;26(1):33. PMID: 41286164
Patent

US20180263995A1.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio. 2013 Feb 5;4(1):e00558-12. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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OG-L002 hydrochloride

2 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Pureté et documentation
Références

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OG-L002 hydrochloride

Other In-stock Forms of OG-L002 hydrochloride

Publications Citing Use of MedChemExpress (MCE) OG-L002 hydrochloride

Voir tous les produits spécifiques à Isoform Histone Demethylase

Voir tous les produits spécifiques à Isoform Monoamine Oxidase

Voir tous les produits spécifiques à Isoform HSV