1. Epigenetics
  2. Histone Demethylase
  3. ML324

ML324 

Cat. No.: HY-12725 Purity: >98.0%
Handling Instructions

ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.

For research use only. We do not sell to patients.

ML324 Chemical Structure

ML324 Chemical Structure

CAS No. : 1222800-79-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 103 In-stock
Estimated Time of Arrival: December 31
10 mg USD 94 In-stock
Estimated Time of Arrival: December 31
50 mg USD 306 In-stock
Estimated Time of Arrival: December 31
100 mg USD 540 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity. IC50 value: 920 nM(JMJD2E) [1] Target: JMJD2 demethylase inhibitor ML324 is a probe molecule that displays submicromolar inhibitory activity toward JMJD2E (in vitro) and possesses excellent in vitro ADME properties. In contrast to previously reported inhibitors of the JMJD proteins, ML324 displays excellent cell permeability providing an opportunity for more extensive cell-based studies of JMJD2 enzymes to be undertaken. In addition, ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (94.44 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8618 mL 14.3090 mL 28.6180 mL
5 mM 0.5724 mL 2.8618 mL 5.7236 mL
10 mM 0.2862 mL 1.4309 mL 2.8618 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

349.43

Formula

C₂₁H₂₃N₃O₂

CAS No.

1222800-79-4

SMILES

O=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
ML324
Cat. No.:
HY-12725
Quantity:

ML324

Cat. No.: HY-12725