1. Epigenetics
    Anti-infection
  2. Histone Demethylase
    HSV
    CMV
  3. ML324

ML324 

Cat. No.: HY-12725 Purity: 98.60%
Handling Instructions

ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression.

For research use only. We do not sell to patients.

ML324 Chemical Structure

ML324 Chemical Structure

CAS No. : 1222800-79-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 103 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 103 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 94 In-stock
Estimated Time of Arrival: December 31
50 mg USD 306 In-stock
Estimated Time of Arrival: December 31
100 mg USD 540 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression[1][2].

IC50 & Target

IC50: JMJD2[1], 4.9 μM (KDM4B)[2]

In Vitro

ML324 produces a significant reduction in Aa-LPS-induced osteoclastogenesis in osteoclast progenitors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

349.43

Formula

C21H23N3O2

CAS No.
SMILES

O=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (89.43 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8618 mL 14.3090 mL 28.6180 mL
5 mM 0.5724 mL 2.8618 mL 5.7236 mL
10 mM 0.2862 mL 1.4309 mL 2.8618 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.95 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.60%

References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
ML324
Cat. No.:
HY-12725
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