Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity

Ganesha Rai  1 ,  Akane Kawamura  2 ,  Anthony Tumber  2 ,  Yu Liang  3 ,  Jodi L. Vogel  3 ,  Jesse H. Arbuckle  3 ,  Nathan R. Rose  4 ,  Thomas S. Dexheimer  1 ,  Timothy L. Foley  1 ,  Oliver N. King  4 ,  Amy Quinn  1 ,  Bryan T. Mott  1 ,  Christopher J. Schofield  4 ,  Udo Oppermann  2 ,  Ajit Jadhav  1 ,  Anton Simeonov  1 ,  Thomas M. Kristie  3 ,  David J. Maloney  1
Affiliations
  • 1. NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, 9800 Medical Center Drive, Rockville, MD, 20850
  • 2. Structural Genomics Consortium, University of Oxford, UK
  • 3. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892
  • 4. Department of Chemistry, University of Oxford, UK
PMID: 24260783
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