1. Epigenetics
  2. Histone Demethylase
  3. GSK-J2

GSK-J2 

Cat. No.: HY-15648A Purity: 98.82%
Handling Instructions

GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

For research use only. We do not sell to patients.

GSK-J2 Chemical Structure

GSK-J2 Chemical Structure

CAS No. : 1394854-52-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
10 mg USD 156 In-stock
Estimated Time of Arrival: December 31
50 mg USD 624 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of GSK-J2:

Top Publications Citing Use of Products

Publications Citing Use of MCE GSK-J2

    GSK-J2 purchased from MCE. Usage Cited in: Front Mol Neurosci. 2017 Mar 13;10:51.

    GSK-J1 impaired zebrafish hair cell regeneration. 5 dpf larvae are treated with 400 μM Neomycin for 1 h followed by GSK-J1 exposure for 24 in the presence of BrdU. GSK-J1 significantly reduces the numbers of myosinVI-positive (green) hair cells and BrdU-positive (red) replicating cells.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

    In Vitro

    GSK-J2 is an isomer of GSK-J1, and shows poor activity towards KDM6A and KDM6B, with IC50 of > 100 μM and 49 μM, respectively[1].

    Molecular Weight

    389.45

    Formula

    C₂₂H₂₃N₅O₂

    CAS No.

    1394854-52-4

    SMILES

    O=C(O)CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 42 mg/mL (107.84 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5677 mL 12.8386 mL 25.6772 mL
    5 mM 0.5135 mL 2.5677 mL 5.1354 mL
    10 mM 0.2568 mL 1.2839 mL 2.5677 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    • Molarity Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Keywords:

    GSK-J2Histone DemethylaseInhibitorinhibitorinhibit

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    Product name:
    GSK-J2
    Cat. No.:
    HY-15648A
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