2. Epigenetics Anti-infection
  3. Parasite Histone Demethylase
  4. GSK-J5

GSK-J5 is a potent inhibitor of Schistosome and worm. GSK-J5 increases schistosomula mortality and adult worm motility and mortality, as well as egg oviposition, in a dose- and time-dependent manner.

For research use only. We do not sell to patients.

GSK-J5 Chemical Structure

GSK-J5 Chemical Structure

CAS No. : 1394854-51-3

Size Price Stock Quantity
Oil + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 147 In-stock
Solution
10 mM * 1 mL in DMSO USD 147 In-stock
Oil
1 mg USD 50 In-stock
5 mg USD 160 In-stock
10 mg USD 260 In-stock
25 mg USD 570 In-stock
50 mg USD 950 In-stock
100 mg USD 1500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GSK-J5:

GSK-J5 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE GSK-J5

View All Parasite Isoform Specific Products:

View All Isoforms

View All Histone Demethylase Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GSK-J5 is a potent inhibitor of Schistosome and worm. GSK-J5 increases schistosomula mortality and adult worm motility and mortality, as well as egg oviposition, in a dose- and time-dependent manner[1].

IC50 & Target

Schistosome

 

In Vitro

GSK-J5 (30 μM; 24-96 h) inhibits Schistosome and (5 μM and 20 μM; 24 h) inhibit worms, and promotes minor alterations in worm motility[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK-J5 Related Antibodies
Molecular Weight

417.50

Formula

C24H27N5O2
CAS No.
Appearance

Oil

Color

Light brown to brown

SMILES

O=C(OCC)CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (299.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3952 mL 11.9760 mL 23.9521 mL
5 mM 0.4790 mL 2.3952 mL 4.7904 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3952 mL 11.9760 mL 23.9521 mL 59.8802 mL
5 mM 0.4790 mL 2.3952 mL 4.7904 mL 11.9760 mL
10 mM 0.2395 mL 1.1976 mL 2.3952 mL 5.9880 mL
15 mM 0.1597 mL 0.7984 mL 1.5968 mL 3.9920 mL
20 mM 0.1198 mL 0.5988 mL 1.1976 mL 2.9940 mL
25 mM 0.0958 mL 0.4790 mL 0.9581 mL 2.3952 mL
30 mM 0.0798 mL 0.3992 mL 0.7984 mL 1.9960 mL
40 mM 0.0599 mL 0.2994 mL 0.5988 mL 1.4970 mL
50 mM 0.0479 mL 0.2395 mL 0.4790 mL 1.1976 mL
60 mM 0.0399 mL 0.1996 mL 0.3992 mL 0.9980 mL
80 mM 0.0299 mL 0.1497 mL 0.2994 mL 0.7485 mL
100 mM 0.0240 mL 0.1198 mL 0.2395 mL 0.5988 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

GSK-J5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-J51394854-51-3ParasiteHistone DemethylaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GSK-J5
Cat. No.:
HY-15648C
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.