1. Epigenetics
  2. Histone Demethylase
  3. GSK-J5 hydrochloride

GSK-J5 hydrochloride 

Cat. No.: HY-15648H
Handling Instructions

GSK-J5 hydrochloride is a cell-permeable ester derivative of GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an isomer of GSK-J4 (HY-15648B) and often used as a negative group.

For research use only. We do not sell to patients.

GSK-J5 hydrochloride Chemical Structure

GSK-J5 hydrochloride Chemical Structure

CAS No. : 1797983-32-4

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Description

GSK-J5 hydrochloride is a cell-permeable ester derivative of GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an isomer of GSK-J4 (HY-15648B) and often used as a negative group[1].

In Vitro

GSK-J5 (25 μM) has no effects at inhibiting the LPS-induced response of human primary macrophages derived from healthy volunteers. While GSK-J4 significantly reduced the expression of 16 of 34 LPS-driven cytokines as assessed by PCR array, such as TNF-α[1].
GSK-J5 (30 μM; 6 hours) is the inactive isomer of GSK-J4, has no effect on TNF-α protein production. But neither GSK-J4 nor GSK-J5 directly affects the levels of LPS-induced JMJD3 or of LPS-independent UTX and EZH2[1].
GSK-J5 (30 μM; 1 hour) can not prevent the LPS-induced loss of H3K27me3 associated with the TNFA TSS or block the recruitment of RNA polymerase II to this locus but GSK-J5 can. Finally, GSK-J4, but not GSK-J5, blocks the production of TNF-α by macrophages derived from patients with rheumatoid arthritis[1].

Molecular Weight

453.96

Formula

C₂₄H₂₈ClN₅O₂

CAS No.

1797983-32-4

SMILES

O=C(OCC)CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC4=CC=CC=C4CC3)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

GSK-J5Histone DemethylaseNegativeester derivativeisomer,derivativeInhibitorinhibitorinhibit

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GSK-J5 hydrochloride
Cat. No.:
HY-15648H
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