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Cat. No.: HY-15648D

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GSK-J1 lithium salt

Name: GSK-J1 lithium salt
Brand: MedChemExpress
SKU: HY-15648D
Price: 45.00 USD
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Rating: 5 (17 reviews)

17 Cited Publications

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Based on 17 publication(s) in Google Scholar

GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC₅₀ of 60 nM towards KDM6B.

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Pureté : 98.33%
CAS No.: 2309668-29-7
Formule: C₂₂H₂₂LiN₅O₂
Masse moléculaire:395.38

Stockage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

GSK-J1 lithium salt Chemical Structure

CAS No.: 2309668-29-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (17)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC₅₀ of 60 nM towards KDM6B.

IC₅₀ & Target

KDM6

Voir tous les produits spécifiques à Isoform Histone Demethylase :

In Vitro

GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner^[1]. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC₅₀ of 11 μM and 94 μM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2309668-29-7
Appearance Solid
Masse moléculaire 395.38
Formule C₂₂H₂₂LiN₅O₂
Color White to off-white
SMILES

[Li]OC(CCNC1=NC(C2=NC=CC=C2)=NC(N(CC3)CCC4=C3C=CC=C4)=C1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (17)

All Bio/Physico-chemical AssayIn Vivo ImagingWBIHC

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Journal Impact Factor

Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
J Exp Clin Cancer Res

Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma. [Abstract]

2024 May 30;43(1):152. PMID: 38812060
Adv Sci (Weinh)

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis-Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish. [Abstract]

2025 Dec 12:e13762. PMID: 41387107

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 12:e13762. [Abstract]

WISH analysis of gata1a and hbbe3 expression in nap1l4a ^−/− and WT embryos and in embryos treated with GSK‐J1 (10 μM) at 24 hpf, and box and whisker plots show relative transcriptional levels across groups.

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 12:e13762. [Abstract]

Protein levels of H3K27me3 in nap1l4a ^−/− and WT embryos and in embryos treated with GSK‐J1 (10 μM) at 24 hpf, and graphs show the relative protein levels.
Acta Pharmacol Sin

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib. [Abstract]

2022 Feb;43(2):457-469. PMID: 33850273
Oncogene

BRD4 inhibition sensitizes cervical cancer to radiotherapy by attenuating DNA repair. [Abstract]

2021 Apr;40(15):2711-2724. PMID: 33712705
Clin Exp Med

Corin: a dual inhibitor for KDM1A/HDAC1, suppresses hepatocellular carcinoma by triggering cuproptosis. [Abstract]

2025 Nov 25;26(1):33. PMID: 41286164
iScience

Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition. [Abstract]

2024 May 16;27(6):110011. PMID: 38868181
Front Mol Neurosci

Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts. [Abstract]

2017 Mar 13:10:51. PMID: 28348517

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: Front Mol Neurosci. 2017 Mar 13:10:51. [Abstract]

GSK-J1 impaired zebrafish hair cell regeneration. 5 dpf larvae are treated with 400 μM Neomycin for 1 h followed by GSK-J1 exposure for 24 in the presence of BrdU. GSK-J1 significantly reduces the numbers of myosinVI-positive (green) hair cells and BrdU-positive (red) replicating cells.
Mol Divers

Exploring host epigenetic enzymes as targeted therapies for visceral leishmaniasis: in silico design and in vitro efficacy of KDM6B and ASH1L inhibitors. [Abstract]

2024 Dec;28(6):4403-4424. PMID: 38522046
J Chromatogr A

Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis. [Abstract]

2020 Feb 22:1613:460625. PMID: 31668999
Mol Carcinog

KDM6A Exhibits Antitumor Activities Toward Ovarian Cancer by Epigenetically Activating Transcription of ISG-15. [Abstract]

2025 Nov 18. PMID: 41252674
Res Sq

2025 Aug 12.
bioRxiv

Loss of vitamin C biosynthesis protects from a parasitic infection. [Abstract]

2025 Jul 26:2025.07.22.666193. PMID: 40777373

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Jul 26:2025.07.22.666193. [Abstract]

Morphology and number of normal eggs per well laid by virgin females treated with BATT and either GSK-J2 or GSK-J1.

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Jul 26:2025.07.22.666193. [Abstract]

DAPI and Fast BBB staining showing the ovary (left) and vitellaria (right) of virgin females treated with BATT and either GSK-J2 or GSK-J1.
SSRN

2021 Dec.
Patent

US20200376146A1.
Patent

US20200376102A1.
Patent

US20180263995A1.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8. [Content Brief]

[2]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2 [Content Brief]

[3]. Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291(6):2631-46. [Content Brief]

Calculators

Calculateur de molarité

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

GSK-J1 lithium salt

17 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (17)
Pureté et documentation
Références

1/16
1/16

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 12:e13762. [Abstract]

Customer Validation
WISH analysis of gata1a and hbbe3 expression in nap1l4a ^−/− and WT embryos and in embryos treated with GSK‐J1 (10 μM) at 24 hpf, and box and whisker plots show relative transcriptional levels across groups.
1/16

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 12:e13762. [Abstract]

Customer Validation
Protein levels of H3K27me3 in nap1l4a ^−/− and WT embryos and in embryos treated with GSK‐J1 (10 μM) at 24 hpf, and graphs show the relative protein levels.
1/16

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Jul 26:2025.07.22.666193. [Abstract]

Customer Validation
Morphology and number of normal eggs per well laid by virgin females treated with BATT and either GSK-J2 or GSK-J1.
1/16

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Jul 26:2025.07.22.666193. [Abstract]

Customer Validation
DAPI and Fast BBB staining showing the ovary (left) and vitellaria (right) of virgin females treated with BATT and either GSK-J2 or GSK-J1.
1/16

GSK-J1 lithium salt purchased from MedChemExpress. Usage Cited in: Front Mol Neurosci. 2017 Mar 13:10:51. [Abstract]

Customer Validation
GSK-J1 impaired zebrafish hair cell regeneration. 5 dpf larvae are treated with 400 μM Neomycin for 1 h followed by GSK-J1 exposure for 24 in the presence of BrdU. GSK-J1 significantly reduces the numbers of myosinVI-positive (green) hair cells and BrdU-positive (red) replicating cells.

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GSK-J1 lithium salt

Publications Citing Use of MedChemExpress (MCE) GSK-J1 lithium salt

Voir tous les produits spécifiques à Isoform Histone Demethylase