GSK-J2 sodium
Based on 4 publication(s) in Google Scholar
GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.
For research use only. We do not sell to patients.
- CAS No.: 2108665-15-0
- Formula: C22H22N5NaO2
- Molecular Weight:411.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) GSK-J2 sodium
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IHC
Biological Activity
Chemical Information
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CAS No. 2108665-15-0
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Molecular Weight 411.43
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Formula C22H22N5NaO2
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SMILES
O=C(CCNC1=CC(N2CCC3=C(CC2)C=CC=C3)=NC(C4=CN=CC=C4)=N1)O[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
KDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers. [Abstract]2025 Jul 14;16(1):523. PMID: 40659611 -
Mol Divers
Exploring host epigenetic enzymes as targeted therapies for visceral leishmaniasis: in silico design and in vitro efficacy of KDM6B and ASH1L inhibitors. [Abstract]2024 Dec;28(6):4403-4424. PMID: 38522046 -
Front Mol Neurosci
Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts. [Abstract]2017 Mar 13;10:51. PMID: 28348517
GSK-J2 sodium purchased from MedChemExpress. Usage Cited in: Front Mol Neurosci. 2017 Mar 13;10:51. [Abstract]
GSK-J1 impaired zebrafish hair cell regeneration. 5 dpf larvae are treated with 400 μM Neomycin for 1 h followed by GSK-J1 exposure for 24 in the presence of BrdU. GSK-J1 significantly reduces the numbers of myosinVI-positive (green) hair cells and BrdU-positive (red) replicating cells.
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bioRxiv
2025 Jul 26:2025.07.22.666193. PMID: 40777373
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)