GSK-J1 sodium
GSK-J1 sodium is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 value of 60 nM towards KDM6B.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1797832-71-3
- Fòrmula: C22H22N5NaO2
- Peso molecular:411.43
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-15648F
GSK-J4 hydrochlorideJMJD3/UTX Inhibitor -
HY-101928
KDM4D-IN-1KDM4D Inhibitor -
HY-107573
KDM2/7-IN-1KDM2/7 Inhibitor -
HY-13953
JIB-04Histone Demethylase Inhibitor -
HY-12725
ML324JMJD2 Inhibitor -
HY-12635
SP2509LSD1 Antagonist -
HY-15648I
GSK-J2 sodiumInactive Isomer of GSK-J1 -
HY-135146
GSK-3484862DNMT1 Inhibitor -
HY-100744
AS8351KDM5B Inhibitor -
HY-15648B
GSK-J4JMJD3/UTX Inhibitor -
HY-15648FR
GSK-J4 hydrochloride (Standard)JMJD3/UTX Inhibitor -
HY-101928R
KDM4D-IN-1 (Standard)Reference Standard
Actividad biológica
Descripciòn
IC50 & Target
IC50: 60 nM (KDM6B)[2]
Chemical Information
-
No. CAS 1797832-71-3
-
Peso molecular 411.43
-
Fòrmula C22H22N5NaO2
-
SMILES
O=C(CCNC1=CC(N2CCC3=C(CC2)C=CC=C3)=NC(C4=CC=CC=N4)=N1)O[Na]
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8. [Content Brief]
[2]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2. [Content Brief]
[3]. Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291(6):2631-46. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK-J1 sodium Related Classifications
HY-15648G Related Classifications
Powered by Bioz