KDM2/7-IN-1
Based on 1 publication(s) in Google Scholar
KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro.
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- Reinheit: 99.9%
- CAS. Nr.: 1453071-47-0
- Formel: C15H27NO4
- Molecular Weight:285.38
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) KDM2/7-IN-1
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Biologische Aktivität
Beschreibung
IC50 & Target
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KDM2 |
KDM4 |
KDM7 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | GI50 |
40 μM
Compound: 9
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Growth inhibition of human HeLa cells after 48 hrs by MTT assay
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
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[PMID: 23964788] |
| KYSE-150 cell line | GI50 |
16 μM
Compound: 9
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Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay
Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay
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[PMID: 23964788] |
| N2a | GI50 |
86 μM
Compound: 9
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Growth inhibition of mouse N2A cells after 48 hrs by MTT assay
Growth inhibition of mouse N2A cells after 48 hrs by MTT assay
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[PMID: 23964788] |
In Vitro
KDM2/7-IN-1 (50 μM, 24 hours) significantly increases H3K27me2 levels in N2a cells[1]. KDM2/7-IN-1 (GI50: 40 μM, 16 μM, 48 hours) significantly inhibits the proliferation of HeLa and KYSE150 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:N2a cells (mouse neuroblastoma)
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Concentration:10 μM and 50 μM
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Incubation Time:24 hours
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Result:Significantly increased H3K27me2 levels in a dose-dependent manner.
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Cell Line:HeLa and KYSE150 cells (cervical and esophageal cancer)
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Concentration:16 μM and 40 μM
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Incubation Time:48 hours
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Result:Significantly inhibited proliferation of HeLa and KYSE150 cells.
Chemical Information
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CAS. Nr. 1453071-47-0
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Appearance Solid
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Molecular Weight 285.38
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Formel C15H27NO4
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Color White to off-white
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SMILES
OC(CCN(O)C(CCCCCCCCC1CC1)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation. [Abstract]2024 Feb 12;15(2):136. PMID: 38346941
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 30 mg/mL (105.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5041 mL | 17.5205 mL | 35.0410 mL | 87.6025 mL |
| 5 mM | 0.7008 mL | 3.5041 mL | 7.0082 mL | 17.5205 mL | |
| 10 mM | 0.3504 mL | 1.7520 mL | 3.5041 mL | 8.7602 mL | |
| 15 mM | 0.2336 mL | 1.1680 mL | 2.3361 mL | 5.8402 mL | |
| 20 mM | 0.1752 mL | 0.8760 mL | 1.7520 mL | 4.3801 mL | |
| 25 mM | 0.1402 mL | 0.7008 mL | 1.4016 mL | 3.5041 mL | |
| 30 mM | 0.1168 mL | 0.5840 mL | 1.1680 mL | 2.9201 mL | |
| 40 mM | 0.0876 mL | 0.4380 mL | 0.8760 mL | 2.1901 mL | |
| 50 mM | 0.0701 mL | 0.3504 mL | 0.7008 mL | 1.7520 mL | |
| 60 mM | 0.0584 mL | 0.2920 mL | 0.5840 mL | 1.4600 mL | |
| 80 mM | 0.0438 mL | 0.2190 mL | 0.4380 mL | 1.0950 mL | |
| 100 mM | 0.0350 mL | 0.1752 mL | 0.3504 mL | 0.8760 mL |
KDM2/7-IN-1 Related Classifications
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