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Cat. No.: HY-107573

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KDM2/7-IN-1

Name: KDM2/7-IN-1
Brand: MedChemExpress
SKU: HY-107573
Price: 76.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC₅₀ values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro.

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Pureté : 99.9%
CAS No.: 1453071-47-0
Formule: C₁₅H₂₇NO₄
Masse moléculaire:285.38

Stockage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

KDM2/7-IN-1 Chemical Structure

CAS No.: 1453071-47-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

KDM2

KDM4

KDM7

Voir tous les produits spécifiques à Isoform Histone Demethylase :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	GI₅₀	40 μM Compound: 9	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 23964788]
KYSE-150 cell line	GI₅₀	16 μM Compound: 9	Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay	[PMID: 23964788]
N2a	GI₅₀	86 μM Compound: 9	Growth inhibition of mouse N2A cells after 48 hrs by MTT assay Growth inhibition of mouse N2A cells after 48 hrs by MTT assay	[PMID: 23964788]

In Vitro

KDM2/7-IN-1 (50 μM, 24 hours) significantly increases H3K27me2 levels in N2a cells^[1].
KDM2/7-IN-1 (GI₅₀: 40 μM, 16 μM, 48 hours) significantly inhibits the proliferation of HeLa and KYSE150 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

N2a cells (mouse neuroblastoma)
Concentration:

10 μM and 50 μM
Incubation Time:

24 hours
Result:

Significantly increased H3K27me2 levels in a dose-dependent manner.

Cell Viability Assay^[1]

Cell Line:

HeLa and KYSE150 cells (cervical and esophageal cancer)
Concentration:

16 μM and 40 μM
Incubation Time:

48 hours
Result:

Significantly inhibited proliferation of HeLa and KYSE150 cells.

Chemical Information

CAS No. 1453071-47-0
Appearance Solid
Masse moléculaire 285.38
Formule C₁₅H₂₇NO₄
Color White to off-white
SMILES

OC(CCN(O)C(CCCCCCCCC1CC1)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Cell Death Dis

Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation. [Abstract]

2024 Feb 12;15(2):136. PMID: 38346941

Solvant et solubilité

In Vitro:

DMSO : 30 mg/mL (105.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5041 mL

17.5205 mL

35.0410 mL

5 mM

0.7008 mL

3.5041 mL

7.0082 mL

10 mM

0.3504 mL

1.7520 mL

3.5041 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Suzuki T, et al. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem. 2013 Sep 26;56(18):7222-31. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5041 mL	17.5205 mL	35.0410 mL	87.6025 mL
	5 mM	0.7008 mL	3.5041 mL	7.0082 mL	17.5205 mL
	10 mM	0.3504 mL	1.7520 mL	3.5041 mL	8.7602 mL
	15 mM	0.2336 mL	1.1680 mL	2.3361 mL	5.8402 mL
	20 mM	0.1752 mL	0.8760 mL	1.7520 mL	4.3801 mL
	25 mM	0.1402 mL	0.7008 mL	1.4016 mL	3.5041 mL
	30 mM	0.1168 mL	0.5840 mL	1.1680 mL	2.9201 mL
	40 mM	0.0876 mL	0.4380 mL	0.8760 mL	2.1901 mL
	50 mM	0.0701 mL	0.3504 mL	0.7008 mL	1.7520 mL
	60 mM	0.0584 mL	0.2920 mL	0.5840 mL	1.4600 mL
	80 mM	0.0438 mL	0.2190 mL	0.4380 mL	1.0950 mL
	100 mM	0.0350 mL	0.1752 mL	0.3504 mL	0.8760 mL

Bioz

Keywords

KDM2/7-IN-1

1 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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KDM2/7-IN-1

Publications Citing Use of MedChemExpress (MCE) KDM2/7-IN-1

Voir tous les produits spécifiques à Isoform Histone Demethylase