Yatein 

Yatein is a lignan isolated from A. chilensis, with antiproliferative activity^[1]. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression^[2].

Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells^[3].
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells^[3].
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

400.42

C₂₂H₂₄O₇

40456-50-6

Oil

Colorless to light yellow

O=C1OC[C@H](CC2=CC=C(OCO3)C3=C2)[C@H]1CC4=CC(OC)=C(OC)C(OC)=C4

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Donoso-Fierro C, et al. Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. Pharm Biol. 2015 Mar;53(3):378-85.  [Content Brief]

  [2]. Kuo YC, et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 2006 Jul;70(3):112-20.  [Content Brief]

  [3]. Shang-Tse Ho, et al. Molecular Mechanisms Underlying Yatein-Induced Cell-Cycle Arrest and Microtubule Destabilization in Human Lung Adenocarcinoma Cells. Cancers (Basel). 2019 Sep; 11(9): 1384.  [Content Brief]