2. Yatein

Yatein is a lignan isolated from A. chilensis, with antiproliferative activity. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression.

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Yatein Chemical Structure

Yatein Chemical Structure

CAS No. : 40456-50-6

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Yatein Related Antibodies

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Description

Yatein is a lignan isolated from A. chilensis, with antiproliferative activity[1]. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression[2].

IC50 & Target

HSV-1[2]
In Vitro

Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells[3].
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells[3].
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Yatein Related Antibodies

Cell Cycle Analysis[3]

Cell Line: A549 cells, CL1-5 cells
Concentration: 1.25 μM , 2.5 μM , 5 μM
Incubation Time: 24 hours
Result: Induced cell-cycle arrest at G2/M phase in both cell lines.

Western Blot Analysis[3]

Cell Line: A549 cells, CL1-5 cells
Concentration: 5 μM
Incubation Time: 6 hours, 12 hours
Result: Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation.
In Vivo

Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft[3]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, five times per week, for 42 days
Result: Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation.
Molecular Weight

400.42

Formula

C22H24O7
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C1OC[C@H](CC2=CC=C(OCO3)C3=C2)[C@H]1CC4=CC(OC)=C(OC)C(OC)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Yatein40456-50-6Inhibitorinhibitorinhibit

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