Gallic aldehyde
Based on 1 publication(s) in Google Scholar
Gallic aldehyde (3,4,5-Trihydroxybenzaldehyde) is a phenolic aldehyde. Gallic aldehyde can be isolated from Geum japonicum. Gallic aldehyde inhibits the gelatinolytic activity and expression of MMP-9. Gallic aldehyde also inhibits ERK1/2, p38, and JNK. Gallic aldehyde has potent anti-HSV-1 and antioxidant activities. Gallic aldehyde also exhibits antibacterial activity against Oenococcus oeni VF.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 13677-79-7
- Formula: C7H6O4
- Molecular Weight:154.12
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Gallic aldehyde
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Biological Activity
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ERK1 |
ERK2 |
MMP-9 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
7.3 μM
Compound: 4
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Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
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[PMID: 25752525] |
| HBL-100 | GI50 |
72 μM
Compound: 4
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Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay
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[PMID: 25752525] |
| HeLa | GI50 |
16 μM
Compound: 4
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Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
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[PMID: 25752525] |
| SW1573 | GI50 |
38 μM
Compound: 4
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Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay
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[PMID: 25752525] |
| T47D | GI50 |
43 μM
Compound: 4
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Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay
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[PMID: 25752525] |
| WiDr | GI50 |
39 μM
Compound: 4
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Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay
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[PMID: 25752525] |
Gallic aldehyde (12.5-50.0 μg/mL) shows potent antiviral activity against HSV-1 with no cytotoxicity in Vero cells[1].
Gallic aldehyde exhibits antioxidant activity, scavenging DPPH free radicals (SC50 = 19.5 mg/mL)[2].
Gallic aldehyde (20-500 mg/mL; 2-24 h) inhibits MMP-9 production as well as gelatinolytic activity in TNF-α-induced HASMC cultures[3].
Gallic aldehyde (250-500 mg/L) inhibits the growth of Oenococcus oeni VF in MRS/TJ medium (pH 4.5, 5% ethanol)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human Aortic Smooth Muscle Cells (HASMCs)
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Concentration:10 μg/mL, 50 μg/mL, 200 μg/mL, 500 μg/mL
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Incubation Time:24 h
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Result:Showed no significant cytotoxicity at concentrations up to 200 μg/mL, and the cell growth ratio was 65.6% at 500 μg/mL.
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Cell Line:Human Aortic Smooth Muscle Cells (HASMCs)
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Concentration:20 μg/mL, 50 μg/mL ;100 μg/mL
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Incubation Time:30 s; 5 min; 15 min; 30 min; 2 h; 4 h; 6 h; 8 h
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Result:Inhibited MAPK (ERK1/2, p38, JNK) phosphorylation and NF-κB/AP-1 nuclear translocation.
Chemical Information
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CAS No. 13677-79-7
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Appearance Solid
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Molecular Weight 154.12
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Formula C7H6O4
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Color White to light brown
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SMILES
O=CC1=CC(O)=C(O)C(O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
Solvent & Solubility
DMSO : 116.67 mg/mL (757.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (13.50 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (13.50 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Miwa H, et al. Liquid chromatographic determination of free and total fatty acids in milk and milk products as their 2-nitrophenylhydrazides. J Chromatogr. 1990 Dec 7;523:235-46. [Content Brief]
[3]. Thomas SC, et al. Phytotoxicity and hormesis in common mobile organic compounds in leachates of wood-derived biochars. Biochar. 2024;6(1):51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4885 mL | 32.4423 mL | 64.8845 mL | 162.2113 mL |
| 5 mM | 1.2977 mL | 6.4885 mL | 12.9769 mL | 32.4423 mL | |
| 10 mM | 0.6488 mL | 3.2442 mL | 6.4885 mL | 16.2211 mL | |
| 15 mM | 0.4326 mL | 2.1628 mL | 4.3256 mL | 10.8141 mL | |
| 20 mM | 0.3244 mL | 1.6221 mL | 3.2442 mL | 8.1106 mL | |
| 25 mM | 0.2595 mL | 1.2977 mL | 2.5954 mL | 6.4885 mL | |
| 30 mM | 0.2163 mL | 1.0814 mL | 2.1628 mL | 5.4070 mL | |
| 40 mM | 0.1622 mL | 0.8111 mL | 1.6221 mL | 4.0553 mL | |
| 50 mM | 0.1298 mL | 0.6488 mL | 1.2977 mL | 3.2442 mL | |
| 60 mM | 0.1081 mL | 0.5407 mL | 1.0814 mL | 2.7035 mL | |
| 80 mM | 0.0811 mL | 0.4055 mL | 0.8111 mL | 2.0276 mL | |
| 100 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6221 mL |
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