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Cat. No.: HY-17422B

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Acyclovir monophosphate

Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 66341-16-0
Formula: C₈H₁₂N₅O₆P
Molecular Weight:305.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Acyclovir monophosphate Chemical Structure

CAS No.: 66341-16-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

DNA Polymerase

All DNA/RNA Synthesis Isoforms :

All HSV Isoforms :

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	EC₅₀	20 μM Compound: 14, ACV H-phosphonate, ACV monophosphate	Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs	[PMID: 22954898]
Vero	EC₅₀	41 μM Compound: 14, ACV H-phosphonate, ACV monophosphate	Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs	[PMID: 22954898]
Vero	CC₅₀	>2000 μM Compound: 14, ACV H-phosphonate, ACV monophosphate	Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining	[PMID: 22954898]

Chemical Information

CAS No. 66341-16-0
Molecular Weight 305.18
Formula C₈H₁₂N₅O₆P
SMILES

O=C1N=C(NC2=C1N=CN2COCCOP(O)(O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yao J, et al. Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. J Control Release. 2013 Sep 28;170(3):414-20. [Content Brief]

[2]. Elion GB, et al. Mechanism of action and selectivity of acyclovir. Am J Med. 1982 Jul 20;73(1A):7-13. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Acyclovir monophosphate

High-Throughput Bioactive Compound Library

All DNA/RNA Synthesis Isoforms

All HSV Isoforms

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Acyclovir monophosphate Related Classifications

HY-17422B Related Classifications