1. Metabolic Enzyme/Protease
    Anti-infection
    Membrane Transporter/Ion Channel
  2. Cytochrome P450
    HSV
    SGLT
  3. Kushenol K

Kushenol K 

Cat. No.: HY-117010
Handling Instructions

Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM). Kushenol K also inhibits the activity of SGLT1 and SGLT2.

For research use only. We do not sell to patients.

Kushenol K Chemical Structure

Kushenol K Chemical Structure

CAS No. : 101236-49-1

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Description

Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].

IC50 & Target[1][2][3]

CYP3A4

1.35 μM (Ki)

HSV-2

147 μM (EC50)

SGLT

 

In Vitro

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1].
At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

472.53

Formula

C₂₆H₃₂O₈

CAS No.

101236-49-1

SMILES

COC(C=C1O)=C(C2=O)C(O[[email protected]](C(C=CC(O)=C3)=C3O)[[email protected]@H]2O)=C1C[[email protected]](C(C)=C)CCC(C)(O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Kushenol KCytochrome P450HSVSGLTCYPsHerpes simplex virusSodium-dependent glucose cotransportersCYP3A4flavonoidSGLT1SGLT2HSV-2Inhibitorinhibitorinhibit

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Product Name:
Kushenol K
Cat. No.:
HY-117010
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