Kushenol K 

Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a K_i value of 1.35 μM^[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC₅₀ of 147 μM)^[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2^[3].

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC₅₀ values of 1.62 µM^[1].
At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

472.53

C₂₆H₃₂O₈

101236-49-1

COC(C=C1O)=C(C2=O)C(O[C@H](C(C=CC(O)=C3)=C3O)[C@@H]2O)=C1C[C@H](C(C)=C)CCC(C)(O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.  [Content Brief]

  [2]. E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4.  [Content Brief]

  [3]. Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.  [Content Brief]