2. Immunology/Inflammation Metabolic Enzyme/Protease Anti-infection
  3. Toll-like Receptor (TLR) MMP HSV Antibiotic
  4. FSL-1 TFA

FSL-1 TFA 

Cat. No.: HY-P2036A Purity: 99.76%
COA Handling Instructions

FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

FSL-1 TFA Chemical Structure

FSL-1 TFA Chemical Structure

Size Price Stock Quantity
100 μg USD 160 In-stock

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This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

Other Forms of FSL-1 TFA:

FSL-1 TFA Related Antibodies

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Description

FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1]. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2].

IC50 & Target[1][2]

TLR2

 

HSV-2

 

TLR6

 

MMP-9

 

In Vitro

FSL-1 TFA significantly reduces HSV-2 replication in human vaginal epithelial cells (EC)[1].
FSL-1 TFA induces significant resistance to experimental genital HSV-2 infection through elaboration of a specific cytokine response profile[1].
FSL-1 TFA (50 ng/mL, 24 hours) induces MMP-9 expression at both mRNA and protein levels in human monocytic THP-1 cells[2].
FSL-1 TFA activates the MAP kinase/NF-κB signaling pathway[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FSL-1 TFA Related Antibodies

Cell Viability Assay[1]

Cell Line: V11I, V12I or V19I immortalized human vaginal EC
Concentration: 6 μg or 0.1 μg
Incubation Time: Added at 24, 6 or just prior to HSV-2 inoculation (104pfu/well)
Result: The 6 μg does produced significant reductions when delivered at 24 or 6 h prior to HSV-2 inoculation. The 0.1 μg dose produced reduced HSV-2 replication at 24 or 6 h prior to viral challenge.
In Vivo

FSL-1 TFA application significantly protectes against genital HSV-2 challenge in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss-Webster mice (weighing 20-25 g)[1]
Dosage: 2 or 6 μg
Administration: Delivered vaginally using a positive displacement pipet, prior to or following viral challenge as specified for each experiment.
Result: The 2 μg does delivered 6 h prior to HSV-2 challenge increased the ID50 (260 pfu) and LD50 (660 pfu) by 10-fold compared to DPBS vehicle control.
The single 6 μg dose produced significantly improved outcomes compared to DPBS vehicle application.
Molecular Weight

1780.18

Appearance

Solid

Formula

C82H141F3N14O20S
Sequence Shortening

S-(2, 3-Bispalmitoyloxypropyl)-CGDPKHPKSF
Shipping

Shipping with dry ice.
Storage

-80°C
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (28.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5617 mL 2.8087 mL 5.6174 mL
5 mM 0.1123 mL 0.5617 mL 1.1235 mL
10 mM 0.0562 mL 0.2809 mL 0.5617 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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FSL-1 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

FSL-1FSL1FSL 1Toll-like Receptor (TLR)MMPHSVAntibioticMatrix metalloproteinasesHerpes simplex virusInhibitorinhibitorinhibit

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