1. PI3K/Akt/mTOR
    Stem Cell/Wnt
    Cell Cycle/DNA Damage
    Anti-infection
    Membrane Transporter/Ion Channel
    Autophagy
  2. GSK-3
    CDK
    Parasite
    HIV
    Proton Pump
    Autophagy
  3. Manzamine A hydrochloride

Manzamine A hydrochloride 

Cat. No.: HY-117025A Purity: 99.29%
Handling Instructions

Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 and 1.5μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1.

For research use only. We do not sell to patients.

Manzamine A hydrochloride Chemical Structure

Manzamine A hydrochloride Chemical Structure

CAS No. : 104264-80-4

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1 mg USD 250 In-stock
Estimated Time of Arrival: December 31
5 mg USD 800 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 and 1.5μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1[1][2][3][4].

IC50 & Target[1][2][3]

GSK-3β

10.2 μM (IC50)

CDK5

1.5 μM (IC50)

HIV-1

 

vacuolar ATPases

 

Malaria

 

In Vitro

Manzamine A increases acidity in pancreatic cancer cells and non-malignant Vero cells. manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. Manzamine A (10 µM; 2 hours; AsPC-1 cells) clearly induced an accumulation of p62 confirming an inhibition of autophagosome turnover[2].
Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

585.22

Formula

C₃₆H₄₅ClN₄O

CAS No.
SMILES

O[[email protected]]1(CC/C=C\CCCC2)[[email protected]@]3([H])[[email protected]@](C[[email protected]@]4([H])N3CCCC/C=C\4)(C[[email protected]@]2CC5)[[email protected]]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

Manzamine AGSK-3CDKParasiteHIVProton PumpAutophagyGlycogen synthase kinase-3Glycogen synthase kinase 3Cyclin dependent kinaseHuman immunodeficiency virusmanzaminealkaloidAlzheimer'sdiseasepancreaticcancerantimalarialInhibitorinhibitorinhibit

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Manzamine A hydrochloride
Cat. No.:
HY-117025A
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