104264-80-4
104264-80-4
Chemical Structure
Manzamine A hydrochloride
Synonym(s): Keramamine A hydrochloride
- CAS No.: 104264-80-4
- Formula:C36H45ClN4O
- Molecular Weight:585.22
InChIKey: DIVWQABXFSWTEF-YTGAITGWSA-N
SMILES: O[C@]1(CC/C=C\CCCC2)[C@@]3([H])[C@@](C[C@@]4([H])N3CCCC/C=C\4)(C[N@@]2CC5)[C@]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1.Cl
Biological Activity: Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1[1][2][3][4].
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Manzamine A hydrochloride | 99.66% | Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1. | ||||||||||||||||||||
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Manzamine A | 98.2% | Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1. | ||||||||||||||||||||
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PARP1-IN-7 | 99.80% | PARP1-IN-7 is an inhibitor of poly(ADP-ribose) polymerase-1 (PARP1) as an anticancer agent. | ||||||||||||||||||||
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RANKL-IN-1 | RANKL-IN-1 is a selective and orally active Receptor Activator of Nuclear Factor-κ B Ligand (RANKL) inhibitor with a KD value of 7.6 μM. RANKL-IN-1 exhibits inhibitory activity and selectivity against osteoclastogenesis with an IC50 value of 0.07 μM and SI of 82.57. RANKL-IN-1binds directly to RANKL and blocks the RANKL-induced activation of the NF-κB and MAPK pathways. RANKL-IN-1 can be used for the research of metabolic disease, such as osteoporosis. | |||||||||||||||||||||
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(Z)-Akuammidine | 95.0% | (Z)-Akuammidine ((Z)-Rhazine) is isolated from Gelsemium elegans. | ||||||||||||||||||||
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Janthitrem A | Janthitrem A (11,12-Epoxyjanthitrem B) is a natural product that can be isolated from Penicillium janthinellum. Janthitrem A induces tremors in mice and reduces weight gain and food consumption of porina (Wiseana cervinata) larvae. | |||||||||||||||||||||
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Shearinine B | Shearinine B ((+)-Shearinine B) is an indole-diterpenoid alkaloid that can be found in the marine-derived fungus Penicillium janthinellum Biourge and Eupenicillium shearii. Shearinine B causes mortality in fall armyworm Spodoptera frugiperda and reduces growth rate of Helicoverpa zea larvae. | |||||||||||||||||||||
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Stemmadenine | Stemmadenine is a strychnos-type monoterpenoid indole alkaloid that serves as a biosynthetic precursor of the monoterpenoid indole alkaloid skeleton. | |||||||||||||||||||||
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Janthitrem G | Janthitrem G is a microbial metabolite that can be isolated from cultures of Penicillium. | |||||||||||||||||||||
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Akuammidine | Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties. | |||||||||||||||||||||
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Terpendole I | Terpendole I is a fungal indole diterpenoid and an ACAT inhibitor (IC50 = 145 µM). Terpendole I can be used in studies related to lipid metabolism. | |||||||||||||||||||||
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References
- [1]. Hamann M, et al. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease. J Nat Prod. 2007;70(9):1397-1405. [Content Brief]
- [2]. Kallifatidis G, et al. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells [published correction appears in Mar Drugs. 2014;12(4):2305-7]. Mar Drugs. 2013;11(9):3500-3516. Published 2013 Sep 17. [Content Brief]
- [3]. Winkler JD, et al. Antimalarial activity of a new family of analogues of manzamine A. Org Lett. 2006;8(12):2591-2594. [Content Brief]
- [4]. Palem JR, et al. Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells. Planta Med. 2011;77(1):46-51. [Content Brief]
