Terpendole I
Terpendole I is a fungal indole diterpenoid and an ACAT inhibitor (IC50 = 145 µM). Terpendole I can be used in studies related to lipid metabolism.
For research use only. We do not sell to patients.
- CAS No.: 167612-17-1
- Formula: C27H35NO5
- Molecular Weight:453.57
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
Microbial Metabolite |
In Vitro
Terpendole I weakly inhibits ACAT activity in rat liver microsomes with an IC50 of 145 μM[1].
Terpendole I (1 mg/mL (10 μg/paper disk); 24 h (bacteria); 48 h (fungi, yeasts)) shows no antimicrobial activity against tested bacteria, fungi, and yeasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 167612-17-1
-
Molecular Weight 453.57
-
Formula C27H35NO5
-
SMILES
C[C@@]12[C@@]([H])(CC[C@]3([C@]45[C@]([H])(CC[C@@]32C)O[C@@H]([C@H]([C@H]4O5)O)C(O)(C)C)O)CC6=C1NC7=C6C=CC=C7
-
Structure Classification
-
Initial Source
Albophoma yamanashiensis
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Tomoda H, et al. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components. J Antibiot (Tokyo). 1995;48(8):793-804. [Content Brief]
[2]. Xu LL, et al. Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp. J Nat Prod. 2019;82(2):221-231. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Terpendole I Related Classifications
HY-N8331 Related Classifications
Powered by Bioz