Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components

  • J Antibiot (Tokyo). 1995 Aug;48(8):793-804. doi: 10.7164/antibiotics.48.793.
H Tomoda  1 ,  N Tabata ,  D J Yang ,  H Takayanagi ,  S Omura
Affiliations
  • 1. Research Center for Biological Function, Kitasato Institute, Kitasato University, Tokyo, Japan.
PMID: 7592023 DOI: 10.7164/antibiotics.48.793
Abstract

Eight new components of terpendoles E to L were isolated and characterized from the culture broth of Albophoma yamanashiensis using a different production medium. All the structures were elucidated by spectroscopic analyses including various NMR experiments, indicating that all the terpendoles have the same indoloditerpene core as terpendoles A to D. Terpendoles J, K and L showed the moderate inhibition against acyl-CoA: cholesterol Acyltransferase (ACAT) activity with IC50 values of 38.8, 38.0 and 32.4 microM in rat liver microsomes, respectively. But terpendoles E-I showed weak activities (IC50 145-388 microM).

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