Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,)

  • J Nat Prod. 2008 Mar;71(3):438-44. doi: 10.1021/np700738k.
George R Pettit  1 ,  Fiona Hogan ,  Jun-Ping Xu ,  Rui Tan ,  Toshihiko Nogawa ,  Zbigniew Cichacz ,  Robin K Pettit ,  Jiang Du ,  Qing-Hua Ye ,  Gordon M Cragg ,  Cherry L Herald ,  Michael S Hoard ,  Animesh Goswami ,  Justin Searcy ,  Larry Tackett ,  Dennis L Doubek ,  Lee Williams ,  John N A Hooper ,  Jean M Schmidt ,  Jean-Charles Chapuis ,  Denise N Tackett ,  Felicia Craciunescu
Affiliations
  • 1. Department of Chemstry and Biochemistry, Arizona State University, Tempe, Arizona 85287-2404, USA. [email protected]
PMID: 18327911 DOI: 10.1021/np700738k
Abstract

Bioassay-guided fractionation of extracts of various Plants, marine organisms, and Microorganisms has led to the discovery of new natural sources of a number of known compounds that have significant biological activity. The isolation of interesting and valuable Cancer cell growth inhibitors including majusculamide C ( 1), axinastatin 5 ( 5), bengazoles A ( 6), B ( 7), and E ( 8), manzamine A ( 10), jaspamide ( 11), and neoechinulin A ( 19) has been summarized.