1. Cell Cycle/DNA Damage
    Apoptosis
  2. Nucleoside Antimetabolite/Analog
    Thymidylate Synthase

Trifluorothymidine (Synonyms: Trifluridine; FTD; 5-Trifluorothymidine; NSC 529182; NSC 75520)

Cat. No.: HY-A0061 Purity: 99.69%
Data Sheet SDS Handling Instructions

Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA.

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Trifluorothymidine Chemical Structure

Trifluorothymidine Chemical Structure

CAS No. : 70-00-8

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Other Forms of Trifluorothymidine:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA. IC50 Value: 1 uM ( Hela cell) [1] Target: thymidylate synthase; Nucleoside antimetabolite/analog Trifluorothymidine (TFT) is well known to be converted to TFT-monophosphate by thymidine kinase and to inhibit thymidylate synthase in vitro: When HeLa cells were treated with TFT at a concentration of 1 uM (IC50 value), the concentration of TFT in the DNA was calculated as 62.2±0.9 pmol/1x106 cells for 4 h [1]. Unlike FdUrd and 5FU, TFT resulted in an earlier phosphorylation of ATR and chk1 proteins after only 24 h of exposure, while phosphorylated ATM, BRCA2 and chk2 proteins were detected after more than 48 h of exposure to TFT [2]. SN38 and TFT induced most DNA damage in H630 and Colo320 cells, which was increased in combination. TFT pre-incubation further enhanced SN38-induced DNA strand breaks in H630 and Colo320 (>20%), which was most pronounced in H630 cells (p<0.01) [3]. in vivo: After oral administration of TFT in rats, more than 75% of the TFT was absorbed [4].

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References
Molecular Weight

296.2

Formula

C₁₀H₁₁F₃N₂O₅

CAS No.

70-00-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.69%

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Trifluorothymidine
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