Trifluridine (Standard)
Trifluridine (Standard) is the analytical standard of Trifluridine. This product is intended for research and analytical applications. Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 70-00-8
- Formula: C10H11F3N2O5
- Molecular Weight:296.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 70-00-8
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Molecular Weight 296.20
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Formula C10H11F3N2O5
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SMILES
O[C@H]1C[C@H](N2C(NC(C(C(F)(F)F)=C2)=O)=O)O[C@@H]1CO
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Synonyms
Trifluorothymidine (Standard); 5-Trifluorothymidine (Standard); TFT (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340(2):457-62. [Content Brief]
[2]. Jia HJ, et al. Trifluridine induces HUVECs senescence by inhibiting mTOR-dependent autophagy. Biochem Biophys Res Commun. 2022 Jun 25;610:119-126. [Content Brief]
[3]. Suzuki N,et al. Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer. Oncol Lett. 2017 Jul;14(1):639-646. [Content Brief]
[4]. Li J, et al. Trifluridine selectively inhibits cell growth and induces cell apoptosis of triple-negative breast cancer. Am J Cancer Res. 2020 Feb 1;10(2):507-522. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trifluridine (Standard) Related Classifications
HY-A0061R Related Classifications
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- Trifluridine (Standard)
- 70-00-8
- Trifluorothymidine (Standard)
- 5-Trifluorothymidine (Standard)
- TFT (Standard)
- Reference Standards
- Thymidylate Synthase
- HSV
- Nucleoside Antimetabolite/Analog
- Orthopoxvirus
- DNA/RNA Synthesis
- Apoptosis
- Autophagy
- mTOR
- antitumor
- antiviral
- HUVEC
- cancer
- metastatic colorectal cancer
- gastrointestinal tumor
- Inhibitor
- inhibitor
- inhibit