1. Cell Cycle/DNA Damage
    Apoptosis
  2. Nucleoside Antimetabolite/Analog
    Thymidylate Synthase
  3. Trifluridine/tipiracil hydrochloride mixture

Trifluridine/tipiracil hydrochloride mixture  (Synonyms: TAS-102)

Cat. No.: HY-16478 Purity: 99.99%
COA Handling Instructions

Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.

For research use only. We do not sell to patients.

Trifluridine/tipiracil hydrochloride mixture Chemical Structure

Trifluridine/tipiracil hydrochloride mixture Chemical Structure

CAS No. : 733030-01-8

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Solution
10 mM * 1 mL in Water USD 73 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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Solid
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10 mg USD 110 In-stock
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50 mg USD 319 In-stock
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100 mg USD 495 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Trifluridine/tipiracil hydrochloride mixture:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Trifluridine/tipiracil hydrochloride mixture

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA[1][2].

In Vivo

Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells[2]
Dosage: 150 mg/kg/day
Administration: p.o.; twice a day for 14 days
Result: Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models.
Clinical Trial
Molecular Weight

435.76

Formula

C10H11F3N2O5.1/2C9H11ClN4O2.1/2HCl

CAS No.
SMILES

O=C1N([[email protected]]2C[[email protected]](O)[[email protected]@H](CO)O2)C=C(C(F)(F)F)C(N1)=O.O=C3N([[email protected]]4C[[email protected]](O)[[email protected]@H](CO)O4)C=C(C(F)(F)F)C(N3)=O.O=C5NC(CN6CCCC6=N)=C(Cl)C(N5)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (229.48 mM; Need ultrasonic)

DMF : 20 mg/mL (45.90 mM; Need ultrasonic)

DMSO : 2.34 mg/mL (5.37 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2948 mL 11.4742 mL 22.9484 mL
5 mM 0.4590 mL 2.2948 mL 4.5897 mL
10 mM 0.2295 mL 1.1474 mL 2.2948 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  Saline

    Solubility: 100 mg/mL (229.48 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (114.74 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.99%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Trifluridine/tipiracil hydrochloride mixture
Cat. No.:
HY-16478
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