2. Cell Cycle/DNA Damage Apoptosis
  3. Nucleoside Antimetabolite/Analog Thymidylate Synthase
  4. Trifluridine/tipiracil hydrochloride mixture

Trifluridine/tipiracil hydrochloride mixture  (Synonyms: TAS-102; FTD/TPI)

Cat. No.: HY-16478 Purity: 99.98%
COA Handling Instructions

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Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.

For research use only. We do not sell to patients.

Trifluridine/tipiracil hydrochloride mixture Chemical Structure

Trifluridine/tipiracil hydrochloride mixture Chemical Structure

CAS No. : 733030-01-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 73 In-stock
Solution
10 mM * 1 mL in Water USD 73 In-stock
Solid
5 mg USD 66 In-stock
10 mg USD 110 In-stock
50 mg USD 319 In-stock
100 mg USD 495 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Trifluridine/tipiracil hydrochloride mixture:

Trifluridine/tipiracil hydrochloride mixture Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Trifluridine/tipiracil hydrochloride mixture

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA[1][2].

In Vivo

Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells[2]
Dosage: 150 mg/kg/day
Administration: p.o.; twice a day for 14 days
Result: Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models.
Clinical Trial
Molecular Weight

435.76

Formula

C10H11F3N2O5.1/2C9H11ClN4O2.1/2HCl
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(C(F)(F)F)C(N1)=O.O=C3N([C@H]4C[C@H](O)[C@@H](CO)O4)C=C(C(F)(F)F)C(N3)=O.O=C5NC(CN6CCCC6=N)=C(Cl)C(N5)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (229.48 mM; Need ultrasonic)

DMF : 20 mg/mL (45.90 mM; Need ultrasonic)

DMSO : 2.34 mg/mL (5.37 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2948 mL 11.4742 mL 22.9484 mL
5 mM 0.4590 mL 2.2948 mL 4.5897 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (114.74 mM); Clear solution; Need ultrasonic

  • Protocol 2

    Add each solvent one by one:  Saline

    Solubility: 100 mg/mL (229.48 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.98%

COA (258 KB) HNMR (301 KB) RP-HPLC (243 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF / H2O 1 mM 2.2948 mL 11.4742 mL 22.9484 mL 57.3710 mL
5 mM 0.4590 mL 2.2948 mL 4.5897 mL 11.4742 mL
DMF / H2O 10 mM 0.2295 mL 1.1474 mL 2.2948 mL 5.7371 mL
15 mM 0.1530 mL 0.7649 mL 1.5299 mL 3.8247 mL
20 mM 0.1147 mL 0.5737 mL 1.1474 mL 2.8686 mL
25 mM 0.0918 mL 0.4590 mL 0.9179 mL 2.2948 mL
30 mM 0.0765 mL 0.3825 mL 0.7649 mL 1.9124 mL
40 mM 0.0574 mL 0.2869 mL 0.5737 mL 1.4343 mL
H2O 50 mM 0.0459 mL 0.2295 mL 0.4590 mL 1.1474 mL
60 mM 0.0382 mL 0.1912 mL 0.3825 mL 0.9562 mL
80 mM 0.0287 mL 0.1434 mL 0.2869 mL 0.7171 mL
100 mM 0.0229 mL 0.1147 mL 0.2295 mL 0.5737 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Trifluridine/tipiracil hydrochloride mixture Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trifluridine/tipiracil hydrochloride mixture733030-01-8TAS-102 FTD/TPITAS102TAS 102Nucleoside Antimetabolite/AnalogThymidylate SynthaseoralnucleosideantitumorFTDTPIthymidylate synthaseDNAInhibitorinhibitorinhibit

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