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  3. Tipiracil hydrochloride

Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

For research use only. We do not sell to patients.

Tipiracil hydrochloride Chemical Structure

Tipiracil hydrochloride Chemical Structure

CAS No. : 183204-72-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 60 In-stock
Solution
10 mM * 1 mL in Water USD 60 In-stock
Solid
5 mg USD 54 In-stock
10 mg USD 82 In-stock
25 mg USD 126 In-stock
50 mg USD 165 In-stock
100 mg USD 219 In-stock
200 mg USD 284 In-stock
500 mg   Get quote  
1 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Tipiracil hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

In Vitro

Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells[1].
Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

279.12

Formula

C9H12Cl2N4O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.O=C1C(Cl)=C(CN2C(CCC2)=N)NC(N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (179.13 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

DMF : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5827 mL 17.9134 mL 35.8269 mL
5 mM 0.7165 mL 3.5827 mL 7.1654 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (89.57 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.86%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5827 mL 17.9134 mL 35.8269 mL 89.5672 mL
5 mM 0.7165 mL 3.5827 mL 7.1654 mL 17.9134 mL
10 mM 0.3583 mL 1.7913 mL 3.5827 mL 8.9567 mL
15 mM 0.2388 mL 1.1942 mL 2.3885 mL 5.9711 mL
20 mM 0.1791 mL 0.8957 mL 1.7913 mL 4.4784 mL
25 mM 0.1433 mL 0.7165 mL 1.4331 mL 3.5827 mL
30 mM 0.1194 mL 0.5971 mL 1.1942 mL 2.9856 mL
40 mM 0.0896 mL 0.4478 mL 0.8957 mL 2.2392 mL
50 mM 0.0717 mL 0.3583 mL 0.7165 mL 1.7913 mL
60 mM 0.0597 mL 0.2986 mL 0.5971 mL 1.4928 mL
80 mM 0.0448 mL 0.2239 mL 0.4478 mL 1.1196 mL
100 mM 0.0358 mL 0.1791 mL 0.3583 mL 0.8957 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tipiracil hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Tipiracil hydrochloride
Cat. No.:
HY-A0063
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