Tipiracil hydrochloride
Based on 5 publication(s) in Google Scholar
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 183204-72-0
- Formula: C9H12Cl2N4O2
- Molecular Weight:279.12
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Tipiracil hydrochloride
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Biological Activity
Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells[1].
Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 183204-72-0
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Appearance Solid
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Molecular Weight 279.12
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Formula C9H12Cl2N4O2
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Color White to off-white
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SMILES
[H]Cl.O=C1C(Cl)=C(CN2C(CCC2)=N)NC(N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
Oncol Rep
AZD6738 promotes the tumor suppressive effects of trifluridine in colorectal cancer cells. [Abstract]2023 Mar;49(3):52. PMID: 36734271 -
Mod Rheumatol
Mithramycin has inhibitory effects on gliostatin and matrix metalloproteinase expression induced by gliostatin in rheumatoid fibroblast-like synoviocytes. [Abstract]2018 May;28(3):495-505. PMID: 28741989 -
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Biomed Pharmacother
2021 Jul:139:111672. PMID: 33965731
Solvent & Solubility
H2O : 50 mg/mL (179.13 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
DMF : < 1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (89.57 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9. [Content Brief]
[2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.5827 mL | 17.9134 mL | 35.8269 mL | 89.5672 mL |
| 5 mM | 0.7165 mL | 3.5827 mL | 7.1654 mL | 17.9134 mL | |
| 10 mM | 0.3583 mL | 1.7913 mL | 3.5827 mL | 8.9567 mL | |
| 15 mM | 0.2388 mL | 1.1942 mL | 2.3885 mL | 5.9711 mL | |
| 20 mM | 0.1791 mL | 0.8957 mL | 1.7913 mL | 4.4784 mL | |
| 25 mM | 0.1433 mL | 0.7165 mL | 1.4331 mL | 3.5827 mL | |
| 30 mM | 0.1194 mL | 0.5971 mL | 1.1942 mL | 2.9856 mL | |
| 40 mM | 0.0896 mL | 0.4478 mL | 0.8957 mL | 2.2392 mL | |
| 50 mM | 0.0717 mL | 0.3583 mL | 0.7165 mL | 1.7913 mL | |
| 60 mM | 0.0597 mL | 0.2986 mL | 0.5971 mL | 1.4928 mL | |
| 80 mM | 0.0448 mL | 0.2239 mL | 0.4478 mL | 1.1196 mL | |
| 100 mM | 0.0358 mL | 0.1791 mL | 0.3583 mL | 0.8957 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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