Tipiracil hydrochloride

Cat. No.: HY-A0063 Purity: 98.77%: FAQs
Data Sheet SDS COA Handling Instructions

Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

For research use only. We do not sell to patients.

Tipiracil hydrochloride Chemical Structure

CAS No. : 183204-72-0

Size	Price	Stock	Quantity
Solution
10 mM * 1 mL in Water	USD 73	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 73	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 66	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 99	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 198	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 264	In-stock	Estimated Time of Arrival: December 31
200 mg	USD 343	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Tipiracil hydrochloride:

Trifluridine/tipiracil hydrochloride mixture In-stock
Tipiracil In-stock

5 Publications Citing Use of MCE Tipiracil hydrochloride

Biological Activity
Purity & Documentation
References
Customer Review

Description

Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

In Vitro

Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells^[1].
Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

279.12

Appearance

Solid

Formula

C₉H₁₂Cl₂N₄O₂

CAS No.

183204-72-0

SMILES

[H]Cl.O=C1C(Cl)=C(CN2C(CCC2)=N)NC(N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (179.13 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

DMF : < 1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5827 mL	17.9134 mL	35.8269 mL
5 mM	0.7165 mL	3.5827 mL	7.1654 mL
10 mM	0.3583 mL	1.7913 mL	3.5827 mL

*Please refer to the solubility information to select the appropriate solvent.

Purity & Documentation

Purity: 98.86%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (253 KB) HNMR (166 KB)

Handling Instructions (2659 KB)

References

[1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9. [Content Brief]

[2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001. [Content Brief]