1. PI3K/Akt/mTOR
    NF-κB
    MAPK/ERK Pathway
    Stem Cell/Wnt
  2. Akt
    NF-κB
    MEK
    ERK
  3. Theaflavin 3,3'-digallate

Theaflavin 3,3'-digallate (Synonyms: TF3)

Cat. No.: HY-N1992
Handling Instructions

Theaflavin 3,3'-digallate (TF3), the typical pigment in black tea, is a good antitumor agent. Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM.

For research use only. We do not sell to patients.

Theaflavin 3,3'-digallate Chemical Structure

Theaflavin 3,3'-digallate Chemical Structure

CAS No. : 30462-35-2

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Description

Theaflavin 3,3'-digallate (TF3), the typical pigment in black tea, is a good antitumor agent. Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM[1].

IC50 & Target[1]

Akt

 

NF-κB

 

MEK1

 

MEK2

 

ERK1

 

ERK2

 

Molecular Weight

868.70

Formula

C₄₃H₃₂O₂₀

CAS No.

30462-35-2

SMILES

O=C(C1=CC(O)=C(O)C(O)=C1)O[[email protected]](CC2=C3O)[[email protected]](OC2=CC(O)=C3)C4=C(C=C([[email protected]@H](OC5=CC(O)=CC(O)=C5C6)[[email protected]@H]6OC(C7=CC(O)=C(O)C(O)=C7)=O)C=C(O)C8=O)C8=C(O)C(O)=C4

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Theaflavin 3,3'-digallate
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HY-N1992
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