1. PI3K/Akt/mTOR
    NF-κB
    MAPK/ERK Pathway
    Stem Cell/Wnt
  2. Akt
    NF-κB
    MEK
    ERK
  3. Theaflavin 3,3'-digallate

Theaflavin 3,3'-digallate (Synonyms: TF3)

Cat. No.: HY-N1992 Purity: 99.73%
Handling Instructions

Theaflavin 3,3'-digallate (TF3), the typical pigment in black tea, is a good antitumor agent. Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM.

For research use only. We do not sell to patients.

Theaflavin 3,3'-digallate Chemical Structure

Theaflavin 3,3'-digallate Chemical Structure

CAS No. : 30462-35-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 328 In-stock
Estimated Time of Arrival: December 31
5 mg USD 202 In-stock
Estimated Time of Arrival: December 31
10 mg USD 343 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Theaflavin 3,3'-digallate (TF3), the typical pigment in black tea, is a good antitumor agent. Theaflavin 3,3'-digallate is generally regarded as the effective component for the inhibitory effects against carcinogenesis without adverse side effects by affecting multiple signal transduction pathways, such as upregulating p53 and p21, inhibiting phosphorylation of the cell survival protein Akt and MAPK pathway, downregulation of NF-κB, shifting the ratio between pro-/antiapoptotic proteins. Theaflavin 3,3'-digallate causes a rapid and sustained decrease in phospho-ERK1/2 and -MEK1/2 protein expression. Theaflavin 3,3'-digallate inhibits HCT116 cell growth with an IC50 of 17.26 μM[1].

IC50 & Target[1]

Akt

 

NF-κB

 

MEK1

 

MEK2

 

ERK1

 

ERK2

 

Molecular Weight

868.70

Formula

C₄₃H₃₂O₂₀

CAS No.

30462-35-2

SMILES

O=C(C1=CC(O)=C(O)C(O)=C1)O[[email protected]](CC2=C3O)[[email protected]](OC2=CC(O)=C3)C4=C(C=C([[email protected]@H](OC5=CC(O)=CC(O)=C5C6)[[email protected]@H]6OC(C7=CC(O)=C(O)C(O)=C7)=O)C=C(O)C8=O)C8=C(O)C(O)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (47.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1511 mL 5.7557 mL 11.5115 mL
5 mM 0.2302 mL 1.1511 mL 2.3023 mL
10 mM 0.1151 mL 0.5756 mL 1.1511 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.73%

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Keywords:

Theaflavin 3,3'-digallateTF3TF 3TF-3AktNF-κBMEKERKPKBProtein kinase BNuclear factor-κBNuclear factor-kappaBMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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Product Name:
Theaflavin 3,3'-digallate
Cat. No.:
HY-N1992
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