1. Anti-infection
  2. HSV
    Antibiotic
  3. Valacyclovir hydrochloride

Valacyclovir hydrochloride (Synonyms: Valaciclovir hydrochloride)

Cat. No.: HY-17425A Purity: 99.85%
Handling Instructions

Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral drug for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a prodrug of Aciclovir (HY-17422) .

For research use only. We do not sell to patients.

Valacyclovir hydrochloride Chemical Structure

Valacyclovir hydrochloride Chemical Structure

CAS No. : 124832-27-5

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Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 99 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Valacyclovir hydrochloride:

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1 Publications Citing Use of MCE Valacyclovir hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral drug for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a prodrug of Aciclovir (HY-17422) [1][2][3][4][5].

IC50 & Target[4]

HSV-1

2.9 μg/mL (IC50)

In Vitro

Valacyclovir hydrochloride (Valaciclovir hydrochloride; VACV) uptake was concentration dependent and saturable with a Michaelis-Menten constant and maximum velocity of 1.64 mM and 23.34 nmol/mg protein/5 min, respectively. A very similar Km value was obtained in hPEPT1/CHO cells and in rat and rabbit tissues and Caco-2 cells, suggesting that hPEPT1 dominates the intestinal transport properties of VACV in vitro[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

For treatment of a first episode of genital herpes, a large comparative trial has shown that Valacyclovir hydrochloride (1 g twice a day) is as effective as acyclovir (200 mg five times a day) when given for 10 days. For treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200 mg five times a day) with a treatment period of 5 days. A daily dose of 1 g of valacyclovir is as effective as 2 g daily. Valacyclovir can be administered once a day[1].
The concentrations of acyclovir in serum and CSF were measured at steady state after 6 days of oral treatment with 1,000 mg of valacyclovir three times a day[2].
EC50 values of PE and AC in 3T3 cells were 0.02 and 0.01 ug/ml, while values in BHK cells were 0.2 and 0.03 ug/ml. Treatment of infected immunosuppressed mice and FA and VA (b.i.d., 5.5 days) reduced the proportion with erythema from 100% to 24% and 38%, and eliminated ear paralysis, ear lesions (vesicles, etc) and death. Virus was absent from ear and brainstem by day 6, but reappeared after discontinuation in mice treated with VA[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

360.80

Formula

C13H21ClN6O4

CAS No.
SMILES

N[[email protected]@H](C(C)C)C(OCCOCN1C=NC2=C1N=C(N)NC2=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (277.16 mM; Need ultrasonic)

DMSO : 43.33 mg/mL (120.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7716 mL 13.8581 mL 27.7162 mL
5 mM 0.5543 mL 2.7716 mL 5.5432 mL
10 mM 0.2772 mL 1.3858 mL 2.7716 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.93 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.85%

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Product Name:
Valacyclovir hydrochloride
Cat. No.:
HY-17425A
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