1. Anti-infection
    Metabolic Enzyme/Protease
  2. Bacterial
    HSV
    Antibiotic
    Endogenous Metabolite
  3. Oxytetracycline dihydrate

Oxytetracycline dihydrate 

Cat. No.: HY-B0275B
Handling Instructions

Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity.

For research use only. We do not sell to patients.

Oxytetracycline dihydrate Chemical Structure

Oxytetracycline dihydrate Chemical Structure

CAS No. : 6153-64-6

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Description

Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity[1][2][3].

IC50 & Target[1][3]

HSV-1

 

Bacterial

 

Human Endogenous Metabolite

 

In Vitro

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes[2].

In Vivo

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter[1].
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days[1].

Clinical Trial
Molecular Weight

496.46

Formula

C₂₂H₂₈N₂O₁₁

CAS No.

6153-64-6

SMILES

O=C(C(C1=O)=C(O)[[email protected]@H](N(C)C)[[email protected]]2([H])[[email protected]@H](O)[[email protected]]3([H])[[email protected]](C)(O)C4=C(C(C3=C(O)[[email protected]@]21O)=O)C(O)=CC=C4)N.O.O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Oxytetracycline dihydrateBacterialHSVAntibioticEndogenous MetaboliteHerpes simplex virusproteinsynthesistetracyclineGram-negativeGram-positiveaminoacil-tRNAm-ribosomalHSV-1Inhibitorinhibitorinhibit

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Oxytetracycline dihydrate
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