2. Cell Cycle/DNA Damage Anti-infection Autophagy Apoptosis Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Endogenous Metabolite Apoptosis
  4. Cytarabine-d2

Cytarabine-d2 is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].

For research use only. We do not sell to patients.

Cytarabine-d<sub>2</sub> Chemical Structure

Cytarabine-d2 Chemical Structure

CAS No. : 40632-26-6

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1 mg USD 750 In-stock
5 mg USD 2250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cytarabine-d2:

Cytarabine-d2 Related Antibodies

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  • Purity & Documentation

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Description

Cytarabine-d2 is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cytarabine-d2 Related Antibodies
Molecular Weight

245.23

Formula

C9H11D2N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@](N2C(N=C(C([2H])=C2[2H])N)=O)([H])O[C@@H]([C@H]1O)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (203.89 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0778 mL 20.3890 mL 40.7780 mL
5 mM 0.8156 mL 4.0778 mL 8.1556 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0778 mL 20.3890 mL 40.7780 mL 101.9451 mL
5 mM 0.8156 mL 4.0778 mL 8.1556 mL 20.3890 mL
10 mM 0.4078 mL 2.0389 mL 4.0778 mL 10.1945 mL
15 mM 0.2719 mL 1.3593 mL 2.7185 mL 6.7963 mL
20 mM 0.2039 mL 1.0195 mL 2.0389 mL 5.0973 mL
25 mM 0.1631 mL 0.8156 mL 1.6311 mL 4.0778 mL
30 mM 0.1359 mL 0.6796 mL 1.3593 mL 3.3982 mL
40 mM 0.1019 mL 0.5097 mL 1.0195 mL 2.5486 mL
50 mM 0.0816 mL 0.4078 mL 0.8156 mL 2.0389 mL
60 mM 0.0680 mL 0.3398 mL 0.6796 mL 1.6991 mL
80 mM 0.0510 mL 0.2549 mL 0.5097 mL 1.2743 mL
100 mM 0.0408 mL 0.2039 mL 0.4078 mL 1.0195 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cytarabine-d2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cytarabine-d240632-26-6DNA/RNA SynthesisNucleoside Antimetabolite/AnalogHSVAutophagyEndogenous MetaboliteApoptosisHerpes simplex virusInhibitorinhibitorinhibit

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