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Helioxanthin 8-1

HY-16680

(Helioxanthin analogue 8-1)

Helioxanthin 8-1

Helioxanthin 8-1 Chemical Structure

Helioxanthin 8-1 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM.

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10 mg $500 Backordered
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10 mg €490 Backordered
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Product name: Helioxanthin 8-1
Cat. No.: HY-16680

Helioxanthin 8-1 Data Sheet

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    Purity: >98.0%

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Helioxanthin 8-1

Helioxanthin 8-1 is an analogue of  helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM.
IC50 value: >5/10/1.4/15 uM(HBV/HCV/HSV-1/HIV) [1]
Target: Antiviral agent
The cyclic hydrazide 28(Helioxanthin 8-1) showed the most potent antiHBV activity among those helioxanthin analogues tested. In addition, compound 28 exhibited moderately potent activity against HIV. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam [1]. 8-1 exhibited effective inhibition on DHBV replication. The combination of 8-1 with 3TC resulted in additional anti-DHBV activity. Viral induced cells displayed higher susceptibility to 8-1 treatment than non-induced cells. HBV X protein might not be an essential factor in the initiation of the biological activity of 8-1, as demonstrated by its absence in DHBV [2].
 

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 376.32 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₀H₁₂N₂O₆
CAS No 840529-13-7
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.6573 mL 13.2866 mL 26.5731 mL
5 mM 0.5315 mL 2.6573 mL 5.3146 mL
10 mM 0.2657 mL 1.3287 mL 2.6573 mL

References on Helioxanthin 8-1

Inhibitor Kit

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