79786-01-9
79786-01-9
Chemical Structure
Casuarinin
- CAS No.: 79786-01-9
- Formula:C41H28O26
- Molecular Weight:936.65
InChIKey: MMQXBTULXAEKQE-VSLJGAQWSA-N
SMILES: OC1=C(O)C(O)=C(C2=C(C(O3)=O)C=C(O)C(O)=C2O)C(C(OC[C@@H](OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@@H]3[C@H](OC(C5=C6C(O)=C(O)C(O)=C5)=O)[C@@H](O7)[C@@H](O)C8=C(C6=C(O)C(O)=C8O)C7=O)=O)=C1
Biological Activity: Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO-1, mFasL, sFasL and HSP-70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF-α-induced phosphorylation of MAPK and activation of NF-κB, downregulates the expression of iNOS, NF-κB, COX-2 and ICAM-1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase-3 and elevation of TNF-α, inhibits the growth of Candida albicans, and inhibits HSV-2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Casuarinin | 99.19% | Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO-1, mFasL, sFasL and HSP-70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF-α-induced phosphorylation of MAPK and activation of NF-κB, downregulates the expression of iNOS, NF-κB, COX-2 and ICAM-1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase-3 and elevation of TNF-α, inhibits the growth of Candida albicans, and inhibits HSV-2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections. | ||||||||||||||||||||
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Punicalagin (Standard) | 98.39% | Punicalagin (Standard) is the analytical standard of Punicalagin. This product is intended for research and analytical applications. Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19. | ||||||||||||||||||||
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Phyllanthusiin C | Phyllanthusiin C is a natural product. | |||||||||||||||||||||
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Methyl chebulagate | ||||||||||||||||||||||
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Vescalagin | Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a Ki value of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase. Vescalagin inhibits hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties. | |||||||||||||||||||||
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Chebulagic acid (Standard) | ≥98% | Chebulagic acid (Standard) is the analytical standard of Chebulagic acid. This product is intended for research and analytical applications. Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC50 of 9.76 μM. | ||||||||||||||||||||
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1,3-HHDP-4,6-HHDP-D-Glucopyranoside | 1,3-HHDP-4,6-HHDP-D-Glucopyranoside is a glucopyranoside derivative. | |||||||||||||||||||||
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Castalagin | Castalagin is an orally active natural product with multiple biological activities including antibacterial activity against bacteria and anti-leishmanial activity against Leishmania aethiopica. Castalagin exhibits inhibitory activity against PARP1 and DNA topoisomerase II, with an IC50 of 0.86 μM for bovine PARP1. Castalagin reduces poly (ADP-ribosyl) ation modification in cells. Castalagin binds to the cell envelope of Ruminococcus bromii, increases the ratio of CD8+/FOXP3+CD4+ T cells in the tumor microenvironment, and acts as a prebiotic to enhance the activity of anti-PD-1 therapy. Castalagin induces morphological changes in Leishmania aethiopica promastigotes and inhibits their proliferation. Castalagin inhibits PBP2a-mediated peptidoglycan layer stabilization, disrupts bacterial peptidoglycan assembly, and inhibits and disintegrates bacterial biofilms. Castalagin can be used in research related to diseases such as cancer, leishmaniasis, and bacterial infections. | |||||||||||||||||||||
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Neochebulagic acid | 96.71% | Neochebulagic acid is isolated from Phyllanthus emblica L.. | ||||||||||||||||||||
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Casuarictin | 98.62% | Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research. | ||||||||||||||||||||
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Tellimagrandin II | 98.19% | Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases. | ||||||||||||||||||||
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References
- [1]. Kuo PL, et al. Casuarinin from the bark of Terminalia arjuna induces apoptosis and cell cycle arrest in human breast adenocarcinoma MCF-7 cells. Planta Med. 2005;71(3):237-243. [Content Brief]
- [2]. Kwon DJ, et al. Casuarinin suppresses TNF-α-induced ICAM-1 expression via blockade of NF-κB activation in HaCaT cells. Biochem Biophys Res Commun. 2011;409(4):780-785. [Content Brief]
- [3]. Al-Sayed E, et al. Protective Role of Casuarinin from Melaleuca leucadendra against Ethanol-Induced Gastric Ulcer in Rats. Planta Med. 2020;86(1):32-44. [Content Brief]
- [4]. Souza-Moreira TM, et al. Anti-Candida targets and cytotoxicity of casuarinin isolated from Plinia cauliflora leaves in a bioactivity-guided study. Molecules. 2013;18(7):8095-8108. Published 2013 Jul 9. [Content Brief]
- [5]. Cheng HY, et al. Antiherpes simplex virus type 2 activity of casuarinin from the bark of Terminalia arjuna Linn. Antiviral Res. 2002;55(3):447-455. [Content Brief]
