79786-01-9
Chemical Structure
Casuarinin
- CAS No.: 79786-01-9
- Formula:C41H28O26
- Molecular Weight:936.65
InChIKey: MMQXBTULXAEKQE-VSLJGAQWSA-N
SMILES: OC1=C(O)C(O)=C(C2=C(C(O3)=O)C=C(O)C(O)=C2O)C(C(OC[C@@H](OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@@H]3[C@H](OC(C5=C6C(O)=C(O)C(O)=C5)=O)[C@@H](O7)[C@@H](O)C8=C(C6=C(O)C(O)=C8O)C7=O)=O)=C1
Biological Activity: Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of Candida albicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Casuarinin | 98.24% | Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of Candida albicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections. | ||||||||||||||||||||
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- [1]. Kuo PL, et al. Casuarinin from the bark of Terminalia arjuna induces apoptosis and cell cycle arrest in human breast adenocarcinoma MCF-7 cells. Planta Med. 2005;71(3):237-243. [Content Brief]
- [2]. Kwon DJ, et al. Casuarinin suppresses TNF-α-induced ICAM-1 expression via blockade of NF-κB activation in HaCaT cells. Biochem Biophys Res Commun. 2011;409(4):780-785. [Content Brief]
- [3]. Al-Sayed E, et al. Protective Role of Casuarinin from Melaleuca leucadendra against Ethanol-Induced Gastric Ulcer in Rats. Planta Med. 2020;86(1):32-44. [Content Brief]
- [4]. Souza-Moreira TM, et al. Anti-Candida targets and cytotoxicity of casuarinin isolated from Plinia cauliflora leaves in a bioactivity-guided study. Molecules. 2013;18(7):8095-8108. Published 2013 Jul 9. [Content Brief]
- [5]. Cheng HY, et al. Antiherpes simplex virus type 2 activity of casuarinin from the bark of Terminalia arjuna Linn. Antiviral Res. 2002;55(3):447-455. [Content Brief]
Keywords
