Ganciclovir triphosphate
Ganciclovir triphosphate (GCV-TP) is a competitive DNA polymerase inhibitor and a metabolite of Ganciclovir (HY-13637). Ganciclovir triphosphate can replace Guanine-5'-triphosphate to terminate DNA chain extension, and mimics dGTP (HY-138616) to compete with mammalian DNA polymerases. Ganciclovir triphosphate can be used in research related to HSV infection, retinoblastoma, glioblastoma and colorectal cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 86761-38-8
- Formule: C9H16N5O13P3
- Masse moléculaire:495.17
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis
More
Activité biologique
Description
IC50 & Target
|
DNA Polymerase |
In Vitro
Ganciclovir triphosphate accumulates in U251gfp human glioblastoma bystander cells cocultured with U251tk cells, with levels ranging from 30-80% of those in U251tk cells, dependent on GCV concentration, coculture ratio, and incubation time, and reaching up to ~2000 pmol/107 cells in 50:50 cocultures with 10 μM GCV for 24 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 86761-38-8
-
Masse moléculaire 495.17
-
Formule C9H16N5O13P3
-
SMILES
O=P(O)(OP(O)(OP(O)(O)=O)=O)OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO
-
Synonyms
GCV-TP
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Yi QY, et al. HSV‑TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK. Oncology reports. 2018 Aug;40(2):682-692. [Content Brief]
[2]. Rubsam LZ, et al. Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells. Cancer Res. 1999 Feb 1;59(3):669-75. [Content Brief]
[3]. Sawdon AJ, et al. Polymeric Nanovectors Incorporated with Ganciclovir and HSV- Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy. Molecules (Basel, Switzerland). 2021 Mar 21;26(6):1759. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ganciclovir triphosphate Related Classifications
HY-131605 Related Classifications
Powered by Bioz