Ganciclovir triphosphate
Ganciclovir triphosphate (GCV-TP) is a competitive DNA polymerase inhibitor and a metabolite of Ganciclovir (HY-13637). Ganciclovir triphosphate can replace Guanine-5'-triphosphate to terminate DNA chain extension, and mimics dGTP (HY-138616) to compete with mammalian DNA polymerases. Ganciclovir triphosphate can be used in research related to HSV infection, retinoblastoma, glioblastoma and colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 86761-38-8
- Formula: C9H16N5O13P3
- Molecular Weight:495.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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DNA Polymerase |
Ganciclovir triphosphate accumulates in U251gfp human glioblastoma bystander cells cocultured with U251tk cells, with levels ranging from 30-80% of those in U251tk cells, dependent on GCV concentration, coculture ratio, and incubation time, and reaching up to ~2000 pmol/107 cells in 50:50 cocultures with 10 μM GCV for 24 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 86761-38-8
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Molecular Weight 495.17
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Formula C9H16N5O13P3
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SMILES
O=P(O)(OP(O)(OP(O)(O)=O)=O)OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO
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Synonyms
GCV-TP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yi QY, et al. HSV‑TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK. Oncology reports. 2018 Aug;40(2):682-692. [Content Brief]
[2]. Rubsam LZ, et al. Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells. Cancer Res. 1999 Feb 1;59(3):669-75. [Content Brief]
[3]. Sawdon AJ, et al. Polymeric Nanovectors Incorporated with Ganciclovir and HSV- Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy. Molecules (Basel, Switzerland). 2021 Mar 21;26(6):1759. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ganciclovir triphosphate Related Classifications
HY-131605 Related Classifications
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