Ganciclovir triphosphate disodium solution (100 mM ± 3 mM)
Based on 1 Customer Validation
Ganciclovir triphosphate disodium solution (100 mM ± 3 mM) (GCV-TP disodium) is a competitive DNA polymerase inhibitor and a metabolite of Ganciclovir (HY-13637). Ganciclovir triphosphate disodium solution (100 mM ± 3 mM) can replace Guanine-5'-triphosphate to terminate DNA chain extension, and mimics dGTP (HY-138616) to compete with mammalian DNA polymerases. Ganciclovir triphosphate disodium solution (100 mM ± 3 mM) can be used in research related to HSV infection, retinoblastoma, glioblastoma and colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 98.61%
- Formula: C9H16N5Na2O13P3
- Molecular Weight:541.15
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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DNA Polymerase |
Ganciclovir triphosphate disodium solution (100 mM ± 3 mM) accumulates in U251gfp human glioblastoma bystander cells cocultured with U251tk cells, with levels ranging from 30-80% of those in U251tk cells, dependent on GCV concentration, coculture ratio, and incubation time, and reaching up to ~2000 pmol/107 cells in 50:50 cocultures with 10 μM GCV for 24 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Liquid
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Molecular Weight 541.15
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Formula C9H16N5Na2O13P3
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Color Colorless to light yellow
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SMILES
O=P(O)(OP(O)(OP(O)(O)=O)=O)OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO.[Na].[Na]
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Synonyms
GCV-TP disodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Yi QY, et al. HSV‑TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK. Oncology reports. 2018 Aug;40(2):682-692. [Content Brief]
[2]. Rubsam LZ, et al. Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells. Cancer Res. 1999 Feb 1;59(3):669-75. [Content Brief]
[3]. Sawdon AJ, et al. Polymeric Nanovectors Incorporated with Ganciclovir and HSV- Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy. Molecules (Basel, Switzerland). 2021 Mar 21;26(6):1759. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ganciclovir triphosphate disodium solution (100 mM ± 3 mM) Related Classifications
HY-131605B Related Classifications
Powered by Bioz
- Ganciclovir triphosphate disodium solution (100 mM ± 3 mM)
- GCV-TP disodium
- DNA/RNA Synthesis
- Drug Metabolite
- HSV
- guanine-5'-triphosphate
- HSV-TK-expressing cells
- retinoblastoma
- DNA polymerase
- mammalian DNA polymerases
- DNA chain elongation
- human glioblastoma bystander cells
- apoptosis
- colorectal cancer cells
- dGTP
- Inhibitor
- inhibitor
- inhibit