3030615-13-2
3030615-13-2
Chemical Structure
ABI-5366
- CAS No.: 3030615-13-2
- Formula:C20H18F2N4O3S2
- Molecular Weight:464.51
InChIKey: XYJOATIQTBVHCL-UHFFFAOYSA-N
SMILES: FC1=CC=C(F)C(C2=CC=C(N(CCCN3C4=NC(C)=C(S(=O)(N)=O)S4)C3=O)C=C2)=C1
Biological Activity: ABI-5366 is a blood-brain barrier-penetrant herpes simplex virus (HSV) Helicase-Primase inhibitor with broad-spectrum, potent antiviral activity. ABI-5366 blocks the enzyme complex required for viral replication, thereby inhibiting viral replication. ABI-5366 can be used for research on herpes simplex virus infection and recurrent genital herpes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ABI-5366 | 97.03% | ABI-5366 is a blood-brain barrier-penetrant herpes simplex virus (HSV) Helicase-Primase inhibitor with broad-spectrum, potent antiviral activity. ABI-5366 blocks the enzyme complex required for viral replication, thereby inhibiting viral replication. ABI-5366 can be used for research on herpes simplex virus infection and recurrent genital herpes. | ||||||||||||||||||||
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References
- [1]. Gege C, et al. Structural determinants of nervous system exposure of adibelivir (IM-250) and related herpes helicase-primase inhibitors across animal species. Antiviral research. 2025 Nov;243:106271. [Content Brief]
- [2]. Shen M, et al. ABI-5366, a Potent HSV Helicase-Primase Inhibitor, with Potential for Weekly or Monthly Oral Dosing for Recurrent Genital Herpes. Liver. 2025 Jan 1;1:0-824.
