26612-48-6
Chemical Structure
Caulerpin
- CAS No.: 26612-48-6
- Formula:C24H18N2O4
- Molecular Weight:398.42
IUPAC Name: dimethyl (6E,13E)-5,12-dihydrocycloocta[1,2-b:5,6-b']diindole-6,13-dicarboxylate
InChIKey: PVWALMHWUOWPPA-HCOJNGAVSA-N
SMILES: O=C(OC)C1=CC=2C=3C=CC=CC3NC2C(=CC=4C=5C=CC=CC5NC14)C(=O)OC
Biological Activity: Caulerpin is an orally active natural product with anti-tumor, anti-viral, anti-oxidant, anti-fungal, anti-bacteria and analgesic activities. Caulerpin acts as an inhibitor of mitochondrial ETC complex I and acetylcholinesterase. Caulerpin blocks hypoxia-induced activation of HIF-1α protein, inhibits VEGF secretion and tumor angiogenesis under hypoxic conditions, reduces the expression of NLRP3 and the production of pro-inflammatory cytokines, and suppresses the load of Mycobacterium tuberculosis. Caulerpin can be used in studies related to breast cancer, prostate cancer, tuberculosis and viral infections[1][2][3][4][5].
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Caulerpin | Caulerpin is an orally active natural product with anti-tumor, anti-viral, anti-oxidant, anti-fungal, anti-bacteria and analgesic activities. Caulerpin acts as an inhibitor of mitochondrial ETC complex I and acetylcholinesterase. Caulerpin blocks hypoxia-induced activation of HIF-1α protein, inhibits VEGF secretion and tumor angiogenesis under hypoxic conditions, reduces the expression of NLRP3 and the production of pro-inflammatory cytokines, and suppresses the load of Mycobacterium tuberculosis. Caulerpin can be used in studies related to breast cancer, prostate cancer, tuberculosis and viral infections. | |||||||||||||||||||||
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References
- [1]. Liu Y, et al. The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration. Journal of natural products. 2009 Dec;72(12):2104-9. [Content Brief]
- [2]. Sidrônio MGS, et al. Host-Mediated Antimicrobial Effects and NLRP3 Inflammasome Modulation by Caulerpin and Its Derivatives in Macrophage Models of Mycobacterial Infections. Microorganisms. 2025 Mar 01;13(3):561. [Content Brief]
- [3]. Macedo NRPV, et al. Caulerpin as a potential antiviral drug against herpes simplex virus type 1. Revista Brasileira de Farmacognosia. 2012;22(4):861-867.
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[4]. Esteves PO, et al. Antiviral Effect of Caulerpin Against Chikungunya. Natural Product Communications. 2019;14(10):1-6.
- [5]. de Souza ET, et al. The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa. Marine drugs. 2009 Nov 26;7(4):689-704. [Content Brief]
