24356-66-9
Chemical Structure
Vidarabine monohydrate
- CAS No.: 24356-66-9
- Formula:C10H15N5O5
- Molecular Weight:285.26
IUPAC Name: (2R,3S,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrate
InChIKey: ZTHWFVSEMLMLKT-CAMOTBBTSA-N
SMILES: O[C@H]1[C@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1CO.O
Biological Activity: Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Vidarabine monohydrate | 99.99% | Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Vidarabine monohydrate (Standard) | ≥98% | Vidarabine (monohydrate) (Standard) is the analytical standard of Vidarabine (monohydrate). This product is intended for research and analytical applications. Vidarabine monohydrate is an adenine arabinoside. Vidarabine monohydrate an antiviral agent which is active against herpes simplex viruses (HSV) and varicella zoster viruses. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Whitley R, et al. Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs. 1980 Oct;20(4):267-82. [Content Brief]
- [2]. VanLandingham KE, et al. Relapse of herpes simplex encephalitis after conventional acyclovir therapy. JAMA. 1988;259(7):1051-1053. [Content Brief]
- [3]. Stolk LM, et al. Formulation of a stable vidarabine infusion fluid. Pharm Weekbl Sci. 1983;5(2):57-60. [Content Brief]
