Glycine-13C2,15N,d2
Based on 1 Customer Validation
Glycine-13C2,15N,d2 is the deuterium, 13C and 15N labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
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- Pureza: 98.71%
- No. CAS: 1984075-49-1
- Fòrmula: 13C2H3D215NO2
- Peso molecular:80.06
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1984075-49-1
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Appearance Solid
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Peso molecular 80.06
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Fòrmula 13C2H3D215NO2
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Color White to off-white
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SMILES
[15NH2][13C]([2H])([2H])[13C](O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
H2O : 100 mg/mL (1249.06 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Johnson JW, et al. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 1987 Feb 5-11;325(6104):529-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 12.4906 mL | 62.4532 mL | 124.9063 mL | 312.2658 mL |
| 5 mM | 2.4981 mL | 12.4906 mL | 24.9813 mL | 62.4532 mL | |
| 10 mM | 1.2491 mL | 6.2453 mL | 12.4906 mL | 31.2266 mL | |
| 15 mM | 0.8327 mL | 4.1635 mL | 8.3271 mL | 20.8177 mL | |
| 20 mM | 0.6245 mL | 3.1227 mL | 6.2453 mL | 15.6133 mL | |
| 25 mM | 0.4996 mL | 2.4981 mL | 4.9963 mL | 12.4906 mL | |
| 30 mM | 0.4164 mL | 2.0818 mL | 4.1635 mL | 10.4089 mL | |
| 40 mM | 0.3123 mL | 1.5613 mL | 3.1227 mL | 7.8066 mL | |
| 50 mM | 0.2498 mL | 1.2491 mL | 2.4981 mL | 6.2453 mL | |
| 60 mM | 0.2082 mL | 1.0409 mL | 2.0818 mL | 5.2044 mL | |
| 80 mM | 0.1561 mL | 0.7807 mL | 1.5613 mL | 3.9033 mL | |
| 100 mM | 0.1249 mL | 0.6245 mL | 1.2491 mL | 3.1227 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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