1392816-46-4
1392816-46-4
Chemical Structure
SI-113
- CAS No.: 1392816-46-4
- Formula:C23H24N6O
- Molecular Weight:400.48
IUPAC Name: (E)-2-((4-(phenethylamino)-1-styryl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)ethan-1-ol
InChIKey: LAOYAWHHLUVMFT-NTCAYCPXSA-N
SMILES: OCCNC1=NC(NCCC2=CC=CC=C2)=C3C(N(/C=C/C4=CC=CC=C4)N=C3)=N1
Biological Activity: SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SI-113 | 98.09% | SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy. | ||||||||||||||||||||
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References
- [1]. Marco Radi , et al. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5579-83. [Content Brief]
- [2]. Silvia Matteoni, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202. [Content Brief]
Keywords
