SGK1-IN-3
SGK1-IN-3 (Compound 3a) is an ATP-competitive SGK1 inhibitor with an IC50 of <1 nM against hSGK1. SGK1-IN-3 blocks the activity of CDK family members. SGK1-IN-3 is a P-glycoprotein substrate. SGK1-IN-3 can be used for research on osteoarthritis.
For research use only. We do not sell to patients.
- CAS No.: 2891696-18-5
- Formula: C23H20Cl2N6O3S
- Molecular Weight:531.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SGK1 <1 nM (IC50) |
In Vitro
SGK1-IN-3 potently inhibits recombinant hSGK1 protein, with an IC50 of <1 nM under both 10 μM ATP and 500 μM ATP conditions[1].
SGK1-IN-3 exhibits poor protein kinase selectivity and inhibits multiple off-target kinases at concentrations of <1 μM[1].
SGK1-IN-3 exhibits poor passive permeability across Caco2/TC7 cell monolayers, with a Ptot of <0.1 × 10-7 cm/s[1].
SGK1-IN-3 is metabolically unstable in rodent microsomal preparations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2891696-18-5
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Molecular Weight 531.41
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Formula C23H20Cl2N6O3S
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SMILES
O=C(C1=CC(C2=CC=C(C=C2)NS(=O)(C3=C(C(Cl)=CC=C3)Cl)=O)=NC4=C1C=NN4)N[C@@H]5CCNC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SGK1-IN-3 Related Classifications
HY-142686 Related Classifications
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