SGK1-IN-3 hydrochloride
Based on 1 Customer Validation
SGK1-IN-3 hydrochloride (Compound 3a) is an ATP-competitive SGK1 inhibitor with an IC50 of <1 nM against hSGK1. SGK1-IN-3 hydrochloride blocks the activity of CDK family members. SGK1-IN-3 hydrochloride serves as a P-glycoprotein substrate. SGK1-IN-3 can be used for the research of osteoarthritis.
For research use only. We do not sell to patients.
- Purity: 98.99%
- Formula: C23H21Cl3N6O3S
- Molecular Weight:567.88
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SGK1 <1 nM (IC50) |
SGK1-IN-3 hydrochloride potently inhibits hSGK1, with an IC50 of <1 nM under both 10 μM and 500 μM ATP conditions[1].
SGK1-IN-3 hydrochloride exhibits poor protein kinase selectivity and inhibits multiple off-target kinases at concentrations <1 μM[1].
SGK1-IN-3 hydrochloride exhibits poor passive permeability across Caco2/TC7 cell monolayers, with a Ptot of <0.1 × 10-7 cm/s[1].
SGK1-IN-3 hydrochloride is metabolically unstable in rodent microsomal preparations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 567.88
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Formula C23H21Cl3N6O3S
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Color Light yellow to yellow
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SMILES
O=C(C1=CC(C2=CC=C(C=C2)NS(=O)(C3=C(C(Cl)=CC=C3)Cl)=O)=NC4=C1C=NN4)N[C@@H]5CCNC5.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 125 mg/mL (220.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7609 mL | 8.8047 mL | 17.6094 mL | 44.0234 mL |
| 5 mM | 0.3522 mL | 1.7609 mL | 3.5219 mL | 8.8047 mL | |
| 10 mM | 0.1761 mL | 0.8805 mL | 1.7609 mL | 4.4023 mL | |
| 15 mM | 0.1174 mL | 0.5870 mL | 1.1740 mL | 2.9349 mL | |
| 20 mM | 0.0880 mL | 0.4402 mL | 0.8805 mL | 2.2012 mL | |
| 25 mM | 0.0704 mL | 0.3522 mL | 0.7044 mL | 1.7609 mL | |
| 30 mM | 0.0587 mL | 0.2935 mL | 0.5870 mL | 1.4674 mL | |
| 40 mM | 0.0440 mL | 0.2201 mL | 0.4402 mL | 1.1006 mL | |
| 50 mM | 0.0352 mL | 0.1761 mL | 0.3522 mL | 0.8805 mL | |
| 60 mM | 0.0293 mL | 0.1467 mL | 0.2935 mL | 0.7337 mL | |
| 80 mM | 0.0220 mL | 0.1101 mL | 0.2201 mL | 0.5503 mL | |
| 100 mM | 0.0176 mL | 0.0880 mL | 0.1761 mL | 0.4402 mL |
SGK1-IN-3 hydrochloride Related Classifications
HY-142686A Related Classifications
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